Results 101 to 110 of about 889,948 (287)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Existence of solutions to Burgers equations in a non-parabolic domain
Electronic Journal of Differential Equations, 2018 In this article, we study the semilinear Burgers equation with time variable coefficients, subject to boundary condition in a non-parabolic domain. Some assumptions on the boundary of the domain and on the coefficients of the equation will be imposed.
Yassine Benia, Boubaker-Khaled Sadallah
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Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Weak solutions for quasilinear degenerate parabolic systems
Electronic Journal of Differential Equations, 2006 This paper concerns the initial Dirichlet boundary-value problem for a class of quasilinear degenerate parabolic systems. Due to the degeneracies, the problem does not have classical solutions in general.
Zheng'an Yao, Wenshu Zhou
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Қарағанды университетінің хабаршысы. Математика сериясыIn the paper the second boundary value problem in a rectangular domain for an inhomogeneous third-order partial differential equation with multiple characteristics with constant coefficients was considered.
Ю.П. Апаков, Р.А. Умаров
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Unicity Results Concerning of difference monomials of L-function and a meromorphic function
Ratio MathematicaIn this paper, we study the value distribution of $\mathcal{L}$-function in the extend Selberg class and a non-constant transcendental meromorphic $\mathsf{f}$ function with finitely many zeros of finite order, sharing a polynomial with its difference ...
Harina Waghamore P, Roopa M.
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Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Nonuniqueness and fractional index convolution complementarity problems
Electronic Journal of Differential Equations, 2014 Uniqueness of solutions of fractional index convolution complementarity problems (CCPs) has been shown for index $1+\alpha$ with ...
David E. Stewart
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