Results 121 to 130 of about 250,996 (306)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The Uniqueness of Extremum Estimation [PDF]

Let W denote a family of probability distributions with parameter space Τ, and WG be a subfamily of W depending on a mapping G:Θ -> Τ. Extremum estimations of the parameter vector ν ∈ Θ are considered.
Volker Krätschmer
core  

Existence of Solutions to a System of Fractional $\mathfrak{q}$-Difference Boundary Value Problems

Mathematics
We are investigating the existence of solutions to a system of two fractional q-difference equations containing fractional q-integral terms, subject to multi-point boundary conditions that encompass q-derivatives and fractional q-derivatives of different
Alexandru Tudorache, Rodica Luca
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Dynamic frictional contact for elastic viscoplastic material

Electronic Journal of Differential Equations, 2007
Using a general theory for evolution inclusions, existence and uniqueness theorems are obtained for weak solutions to a frictional dynamic contact problem for elastic visco-plastic material.
Kenneth L. Kuttler
doaj  

Uniqueness of Single Peak Solutions for a Kirchhoff Equation

Mathematics
We deal with the following singular perturbation Kirchhoff equation: −ϵ2a+ϵb∫R3|∇u|2dyΔu+Q(y)u=|u|p−1u,u∈H1(R3), where constants a,b,ϵ>0 and ...
Junhao Lv, Shichao Yi, Bo Sun
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Some remarks about uniquenes of equilibrium for infinite dimensional economies [PDF]

For economies with infinitely many goods, with two different approaches we obtain sufficient conditions for uniqueness of competitive equilibrium. In the second approach we prove that the Mitjushim-Polterovich conditions is a sufficient condition for ...
Elvio Accinelli
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Uniqueness of a meromorphic functions that share one small function and its derivative. [PDF]

, 2016
In this paper we consider the problem of uniqueness of meromorphic functions that share one small function and its derivatives, and obtain two theorems which improve the result of Qingcai Zhang [11]
Husna, V., Harina, P. Waghamore.
core