Results 91 to 100 of about 889,948 (287)
On the Uniqueness of Solution of Magnetostatic Vector‐potential Problems by Three‐dimensional Finite‐element Methods [PDF]
, 1982 In this paper, particular attention is paid to the impact of finite‐element approximation on uniqueness and to approximations implicit in finite element formulations from the uniqueness requirements standpoint.
Davis, W. A. +4 more
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Uniqueness of solutions to singular p-Laplacian equations with subcritical nonlinearity
Advances in Nonlinear Analysis, 2017 We present a geometric approach to the study of quasilinear elliptic p-Laplacian problems on a ball in ℝn${\mathbb{R}^{n}}$ using techniques from dynamical systems.
Maultsby Bevin
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Global solutions of a model of phase transitions for dissipative thermoviscoelastic materials
Electronic Journal of Differential Equations, 2013 We analyze a highly nonlinear system of partial differential equations that may be seen as a model for solidification or melting of certain viscoelastic materials subject to thermal effects; under the assumption that solid parts of the material may ...
Welington Vieira Assuncao +1 more
doaj
Positive solutions for a class of fractional boundary value problems
Nonlinear Analysis, 2016 In this work, by virtue of the Krasnoselskii–Zabreiko fixed point theorem, we investigate the existence of positive solutions for a class of fractional boundary value problems under some appropriate conditions concerning the first eigenvalue of the ...
Jiafa Xu, Zhongli Wei
doaj +1 more source