Results 21 to 30 of about 613,841 (217)

Remyelination varies between and within lesions in multiple sclerosis following bexarotene

Annals of Clinical and Translational Neurology, 2022
Objective In multiple sclerosis chronic demyelination is associated with axonal loss, and ultimately contributes to irreversible progressive disability. Enhancing remyelination may slow, or even reverse, disability. We recently trialled bexarotene versus
J. William L. Brown, Ferran Prados, Daniel R. Altmann, Baris Kanber, Jonathan Stutters, Nick G. Cunniffe, Joanne L. Jones, Zoya G. Georgieva, Edward J. Needham, Cyrus Daruwalla, Claudia Gandini Wheeler‐Kingshott, Peter Connick, Siddharthan Chandran, Robin Franklin, David MacManus, Rebecca Samson, Alasdair Coles, Declan Chard   +17 more
doaj   +1 more source

Expression Pattern of a Mini Human PrP Gene Promoter in Transgenic Mice

Neurobiology of Disease, 2002
The prion protein is central to the pathogenesis of prion diseases, although its exact function remains unclear. Although transgenic mice have been widely utilised in prion research, their PrP expression patterns have not been characterised in detail. We
E.A. Asante, I. Gowland, J.M. Linehan, S.P. Mahal, J. Collinge   +4 more
doaj   +1 more source

Blood Oxygenation Level-Dependent Response to Multiple Grip Forces in Multiple Sclerosis: Going Beyond the Main Effect of Movement in Brodmann Area 4a and 4p

Frontiers in Cellular Neuroscience, 2021
This study highlights the importance of looking beyond the main effect of movement to study alterations in functional response in the presence of central nervous system pathologies such as multiple sclerosis (MS).
Adnan A. S. Alahmadi, Adnan A. S. Alahmadi, Matteo Pardini, Matteo Pardini, Matteo Pardini, Rebecca S. Samson, Egidio D’Angelo, Egidio D’Angelo, Karl J. Friston, Ahmed T. Toosy, Claudia A. M. Gandini Wheeler-Kingshott, Claudia A. M. Gandini Wheeler-Kingshott, Claudia A. M. Gandini Wheeler-Kingshott   +12 more
doaj   +1 more source

A Population‐Based Study on Childhood Aplastic Anemia—Incidence, Outcomes, and Health‐Related Quality of Life

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Childhood aplastic anemia (AA) is a rare disease, and both the disease itself and its treatment cause significant morbidity. We aimed to determine the contemporary incidence of childhood AA in Finland, to compare the clinical characteristics of AA against inherited bone marrow failure syndromes (IBMFS) and refractory cytopenia of ...
Lauri‐Matti Kulmala, Riitta Niinimäki, Tytti Pokka, Anu Huurre, Liisa Järvelä, Sauli Palmu, Tuuli Pöyhönen, Pauliina Utriainen, Henri Aarnivala   +8 more
wiley   +1 more source

Exploring the effectiveness of a COVID-19 contact tracing app using an agent-based model

Scientific Reports, 2020
A contact-tracing strategy has been deemed necessary to contain the spread of COVID-19 following the relaxation of lockdown measures. Using an agent-based model, we explore one of the technology-based strategies proposed, a contact-tracing smartphone app.
Jonatan Almagor, Stefano Picascia
doaj   +1 more source

Patterns of inflammation, microstructural alterations, and sodium accumulation define multiple sclerosis subtypes after 15 years from onset

Frontiers in Neuroinformatics, 2023
IntroductionConventional MRI is routinely used for the characterization of pathological changes in multiple sclerosis (MS), but due to its lack of specificity is unable to provide accurate prognoses, explain disease heterogeneity and reconcile the gap ...
Antonio Ricciardi, Francesco Grussu, Francesco Grussu, Baris Kanber, Baris Kanber, Ferran Prados, Ferran Prados, Ferran Prados, Marios C. Yiannakas, Bhavana S. Solanky, Frank Riemer, Xavier Golay, Wallace Brownlee, Olga Ciccarelli, Olga Ciccarelli, Daniel C. Alexander, Claudia A. M. Gandini Wheeler-Kingshott, Claudia A. M. Gandini Wheeler-Kingshott, Claudia A. M. Gandini Wheeler-Kingshott   +18 more
doaj   +1 more source

Nephrogenic Rests/Nephroblastomatosis in Patients With Unilateral Wilms Tumor Are Not Associated With an Increased Risk of Relapse: An Analysis of Patients Treated on the SIOP‐WT‐2001 Protocol in the SIOP‐UK‐CCLG and SIOP‐GPOH Studies (2001–2022)

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Nephrogenic rests (NRs) and nephroblastomatosis (NBM) are precursor lesions for development of Wilms tumor (WT). Their association with the risk of relapse has not been properly assessed, partly due to misunderstanding of their diagnostic criteria and terminology.
Gordan M. Vujanić, Rhoikos Furtwängler, Tanzina Chowdhury, Christian Vokuhl, Jenny Wegert, Norbert Graf   +5 more
wiley   +1 more source

Sound power of speech between 63 Hz and 20 kHz at a normal vocal effort level

Acta Acustica
This paper reports anechoic measurements of speech (720 IEEE sentences) produced at a normal vocal effort by 12 native British English speakers (six male, six female) over a hemispherical region (1 m radius) on one side of the talker to allow calculation
Hopkins Carl, Graetzer Simone, Seiffert Gary   +2 more
doaj   +1 more source

Opinion: more mouse models and more translation needed for ALS

Molecular Neurodegeneration, 2023
Amyotrophic lateral sclerosis is a complex disorder most of which is ‘sporadic’ of unknown origin but approximately 10% is familial, arising from single mutations in any of more than 30 genes.
Elizabeth M.C. Fisher, Linda Greensmith, Andrea Malaspina, Pietro Fratta, Michael G. Hanna, Giampietro Schiavo, Adrian M. Isaacs, Richard W. Orrell, Thomas J. Cunningham, Abraham Acevedo Arozena   +9 more
doaj   +1 more source

Inteligencia artificial en esclerosis múltiple

Kranion, 2023
La inteligencia artificial (IA) es la rama de la ciencia que tiene como objetivo crear algoritmos capaces de llevar a cabo tareas que normalmente requieren inteligencia humana.
Carmen Tur, Sara Collorone
doaj   +1 more source