Results 41 to 50 of about 33,565 (252)

Optimal Packings of 13 and 46 Unit Squares in a Square [PDF]

open access: yesThe Electronic Journal of Combinatorics, 2010
Let $s(n)$ be the side length of the smallest square into which $n$ non-overlapping unit squares can be packed. We show that $s(m^2-3)=m$ for $m=4,7$, implying that the most efficient packings of 13 and 46 squares are the trivial ones.
openaire   +2 more sources

Remyelination varies between and within lesions in multiple sclerosis following bexarotene

open access: yesAnnals of Clinical and Translational Neurology, 2022
Objective In multiple sclerosis chronic demyelination is associated with axonal loss, and ultimately contributes to irreversible progressive disability. Enhancing remyelination may slow, or even reverse, disability. We recently trialled bexarotene versus
J. William L. Brown   +17 more
doaj   +1 more source

Tiling the unit square with squares and rectangles

open access: yesJournal of Combinatorial Theory, Series A, 1985
Call a rectangle small if it will fit inside the unit square; call a rectangle binary if its dimensions are powers of 2. Theorem 1. If \({\mathcal S}\) is a set of small binary squares having total area greater than 1, some finite subset of \({\mathcal S}\) will tile the unit square. Theorem 2.
openaire   +1 more source

Expression Pattern of a Mini Human PrP Gene Promoter in Transgenic Mice

open access: yesNeurobiology of Disease, 2002
The prion protein is central to the pathogenesis of prion diseases, although its exact function remains unclear. Although transgenic mice have been widely utilised in prion research, their PrP expression patterns have not been characterised in detail. We
E.A. Asante   +4 more
doaj   +1 more source

Blood Oxygenation Level-Dependent Response to Multiple Grip Forces in Multiple Sclerosis: Going Beyond the Main Effect of Movement in Brodmann Area 4a and 4p

open access: yesFrontiers in Cellular Neuroscience, 2021
This study highlights the importance of looking beyond the main effect of movement to study alterations in functional response in the presence of central nervous system pathologies such as multiple sclerosis (MS).
Adnan A. S. Alahmadi   +12 more
doaj   +1 more source

Exploring the effectiveness of a COVID-19 contact tracing app using an agent-based model

open access: yesScientific Reports, 2020
A contact-tracing strategy has been deemed necessary to contain the spread of COVID-19 following the relaxation of lockdown measures. Using an agent-based model, we explore one of the technology-based strategies proposed, a contact-tracing smartphone app.
Jonatan Almagor, Stefano Picascia
doaj   +1 more source

Patterns of inflammation, microstructural alterations, and sodium accumulation define multiple sclerosis subtypes after 15 years from onset

open access: yesFrontiers in Neuroinformatics, 2023
IntroductionConventional MRI is routinely used for the characterization of pathological changes in multiple sclerosis (MS), but due to its lack of specificity is unable to provide accurate prognoses, explain disease heterogeneity and reconcile the gap ...
Antonio Ricciardi   +18 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Opinion: more mouse models and more translation needed for ALS

open access: yesMolecular Neurodegeneration, 2023
Amyotrophic lateral sclerosis is a complex disorder most of which is ‘sporadic’ of unknown origin but approximately 10% is familial, arising from single mutations in any of more than 30 genes.
Elizabeth M.C. Fisher   +9 more
doaj   +1 more source

Inteligencia artificial en esclerosis múltiple

open access: yesKranion, 2023
La inteligencia artificial (IA) es la rama de la ciencia que tiene como objetivo crear algoritmos capaces de llevar a cabo tareas que normalmente requieren inteligencia humana.
Carmen Tur, Sara Collorone
doaj   +1 more source

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