Results 71 to 80 of about 3,126,546 (267)

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

Development of an initial training and evaluation programme for manual lower limb muscle MRI segmentation

European Radiology Experimental
Background Magnetic resonance imaging (MRI) quantification of intramuscular fat accumulation is a responsive biomarker in neuromuscular diseases. Despite emergence of automated methods, manual muscle segmentation remains an essential foundation. We aimed
Jasper M. Morrow, Sachit Shah, Lara Cristiano, Matthew R. B. Evans, Carolynne M. Doherty, Talal Alnaemi, Abeer Saab, Ahmed Emira, Uros Klickovic, Ahmed Hammam, Afnan Altuwaijri, Stephen Wastling, Mary M. Reilly, Michael G. Hanna, Tarek A. Yousry, John S. Thornton   +15 more
doaj   +1 more source

Investigating the relationship between BMI across adulthood and late life brain pathologies

Alzheimer’s Research & Therapy, 2021
Background In view of reported associations between high adiposity, particularly in midlife and late-life dementia risk, we aimed to determine associations between body mass index (BMI), and BMI changes across adulthood and brain structure and pathology ...
Christopher A. Lane, Josephine Barnes, Jennifer M. Nicholas, John W. Baker, Carole H. Sudre, David M. Cash, Thomas D. Parker, Ian B. Malone, Kirsty Lu, Sarah-Naomi James, Ashvini Keshavan, Sarah Buchanan, Sarah Keuss, Heidi Murray-Smith, Andrew Wong, Elizabeth Gordon, William Coath, Marc Modat, David Thomas, Rebecca Hardy, Marcus Richards, Nick C. Fox, Jonathan M. Schott   +22 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Proximal Aorta Flow as a Proxy for Ventricular–Arterial Interaction

Journal of Vascular Diseases
Ventricular–arterial coupling (VAC) describes the dynamic interaction between left ventricular (LV) systolic elastance and the time-varying elastance/impedance of the arterial tree, a relationship that governs the instantaneous generation of aortic flow ...
Marco Pasetto, Alessandro Russo, Lorenzo Peluso, Marcello Ceola Graziadei, Leonardo Gottin   +4 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Generalised boundary shift integral for longitudinal assessment of spinal cord atrophy

NeuroImage, 2020
Spinal cord atrophy measurements obtained from structural magnetic resonance imaging (MRI) are associated with disability in many neurological diseases and serve as in vivo biomarkers of neurodegeneration.
Ferran Prados, Marcello Moccia, Aubrey Johnson, Marios Yiannakas, Francesco Grussu, Manuel Jorge Cardoso, Olga Ciccarelli, Sebastien Ourselin, Frederik Barkhof, Claudia Wheeler-Kingshott   +9 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Trolley Square Apartments

, 2003
aerial view, sited on a former trolley yard, Trolley Square is a 40-unit, affordable, mixed-use project that defines a new standard for beautiful and environmentally responsible urban housing.
Davis Square Architects
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Aktivitets- og leveranseplan pensumlistekonsortiet 2021

, 2020
Aktivitets- og leveranseplan pensumlistekonsortiet 2021.Aktivitets- og leveranseplan pensumlistekonsortiet ...
Unit
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