Results 61 to 70 of about 4,135,250 (349)

Marine harmful algal blooms (HABs) in the United States: History, current status and future trends. [PDF]

Harmful Algae, 2021
Anderson DM, Fensin E, Gobler CJ, Hoeglund AE, Hubbard KA, Kulis DM, Landsberg JH, Lefebvre KA, Provoost P, Richlen ML, Smith JL, Solow AR, Trainer VL.   +12 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Transcriptome analysis illuminates the nature of the intracellular interaction in a vertebrate-algal symbiosis

eLife, 2017
During embryonic development, cells of the green alga Oophila amblystomatis enter cells of the salamander Ambystoma maculatum forming an endosymbiosis.
John A Burns, Huanjia Zhang, Elizabeth Hill, Eunsoo Kim, Ryan Kerney   +4 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

“C-ing” the River: from Companionship to Control to…Catastrophe or Compromise?

Open Rivers, 2017
What humanity needs to do in the coming decades is back off. In our quest for comfort, consumption, stability, and security in our lives, we have done too much with the earth.
Stevan Harrell
doaj   +1 more source

Ted Kaczynski: Evil or Insane?

, 2017
Explores the life of the infamous Unabomber, and demonstrates why his manifesto on society and his extraordinary intelligence makes him the most unique and brilliant serial killer in United States ...
Warren, Drew C.
core  

Restoring the Balance: The Second Amendment Revisited [PDF]

, 1976
In this article, the Second Amendment is analyzed through a discussion of the history of the right to private arms under English common law, the Second Amendment\u27s legislative history and context, and the United States Supreme Court\u27s decision in ...
Caplan, David I.
core   +1 more source

United States-India Relations: Reconciling the H-1B Visa Hike and Framework for Cooperation on Trade and Investment [PDF]

, 2012
This Comment provides a history of the relationship between the United States and India, and recommends a more substantive agreement on bilateral trade and investment, which protects United States domestic interests while competing in the global market ...
Hochberg, Shari B.
core   +2 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source