Results 91 to 100 of about 777,892 (259)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Spherical tokamak physics research in preparation for the operation of NSTX-U

Nuclear Fusion
The National Spherical Torus Experiment Upgrade (NSTX-U) is preparing to resume operation, representing a crucial step toward realizing compact, cost-effective fusion pilot plants.
S. Munaretto, P.O. Adebayo-Ige, H. Anand, G. Avdeeva, S.G. Baek, K. Barada, E. Belli, E.V. Belova, J.W. Berkery, T.N. Bernard, N. Bertelli, P. Bonofiglo, P.T. Bonoli, M.D. Boyer, J. Candy, C.S. Chang, H. Chung, C. Clauser, M. Comanescu, D. Corona, N.A. Crocker, R. De Levante Rodriguez, E.W. DeShazer, A. Diallo, J. Dominski, V.N. Duarte, F. Ebrahimi, E.D. Emdee, S. Ethier, N.M. Ferraro, E.L. Foley, E.D. Fredrickson, M.E. Galante, K.F. Gan, S. Gerhardt, R.J. Goldston, M. Gorelenkova, W. Guttenfelder, R. Hager, F.D. Halpern, J. Halpern, D. Hatch, F. Hoffmann, M.S. Islam, S.C. Jardin, S.M. Kaye, A. Khodak, J.E. Kinsey, A. Kleiner, E. Kolemen, S. Ku, M. Lampert, B. Leard, B.P. LeBlanc, J.B. Lestz, F.M. Levinton, P.-Y. Li, N.C. Logan, N.A. Lopez, R. Lunsford, T. Macwan, R. Maingi, J. McClenaghan, A.G. McLean, J.E. Menard, Y.-S. Na, A.O. Nelson, M. Ono, A. Pajares, A. Pankin, J. Parisi, F.I. Parra, M.S. Parsons, B.S. Patel, M. Podestá, F.M. Poli, M. Porcelli, T. Rafiq, R. Raman, J.D. Riquezes, S.A. Sabbagh, A. Sanchez-Villar, E. Schuster, S. Shiraiwa, T. Singh, S.P. Smith, D. Smith, V.A. Soukhanovskii, G.M. Staebler, B. Stratton, K.E. Thome, M. Tobin, I.U. Uzun-Kaymak, B. Van Compernolle, W.X. Wang, W. Wehner, A.S. Welander, B.D. Wirth, J. Yang, V. Zamkovska, X. Zhang   +100 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

United States of America [PDF]

, 1989
J. Coombs, Y. R. Alston
openaire   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Causal emissions factor benchmarks during contingent nuclear outages

Environmental Research Communications
One method to decrease carbon dioxide (CO _2 ) emissions in the electricity sector is to shift the timing of electric load from periods when it causes more pollution to times when it causes less.
Pierre Christian, Joel Cofield, Sam Koebrich, Gavin McCormick   +3 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

NSTX-U research advancing the physics of spherical tokamaks

Nuclear Fusion
The objectives of NSTX-U research are to reinforce the advantages of STs while addressing the challenges. To extend confinement physics of low- A , high beta plasmas to lower collisionality levels, understanding of the transport mechanisms that set ...
J.W. Berkery, P.O. Adebayo-Ige, H. Al Khawaldeh, G. Avdeeva, S-G. Baek, S. Banerjee, K. Barada, D.J. Battaglia, R.E. Bell, E. Belli, E.V. Belova, N. Bertelli, N. Bisai, P.T. Bonoli, M.D. Boyer, J. Butt, J. Candy, C.S. Chang, C.F. Clauser, L.D. Corona Rivera, M. Curie, P.C. de Vries, R. Diab, A. Diallo, J. Dominski, V.N. Duarte, E.D. Emdee, N.M. Ferraro, R. Fitzpatrick, E.L. Foley, E. Fredrickson, M.E. Galante, K.F. Gan, S. Gerhardt, R. Goldston, W. Guttenfelder, R. Hager, M.O. Hanson, S.C. Jardin, T.G. Jenkins, S.M. Kaye, A. Khodak, J. Kinsey, A. Kleiner, E. Kolemen, S. Ku, M. Lampert, B. Leard, B.P. LeBlanc, J.B. Lestz, F.M. Levinton, C. Liu, T. Looby, R. Lunsford, T. Macwan, R. Maingi, J. McClenaghan, J.E. Menard, S. Munaretto, M. Ono, A. Pajares, J. Parisi, J-K. Park, M.S. Parsons, B.S. Patel, Y.V. Petrov, M. Podestà, F. Poli, M. Porcelli, T. Rafiq, S.A. Sabbagh, Á. Sánchez Villar, E. Schuster, J. Schwartz, A. Sharma, S. Shiraiwa, P. Sinha, D. Smith, S. Smith, V.A. Soukhanovskii, G. Staebler, E. Startsev, B. Stratton, K.E. Thome, W. Tierens, M. Tobin, I.U. Uzun-Kaymak, B. Van Compernolle, J. Wai, W. Wang, W. Wehner, A. Welander, J. Yang, V. Zamkovska, X. Zhang, X.L. Zhu, S. Zweben   +96 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source