Results 81 to 90 of about 3,464,691 (302)

Sustaining Autonomous Communities in the Modern United States (The United Communities of America) [PDF]

open access: yes, 2017
America has become industrialized and characterized by social anxiety and overconsumption. The inability to be sustainable has led the once plentiful and flourishing nation into an ongoing sustainability crisis. Even if there is a deep connection between
Hester, Lucas
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

P1429: MULTIPLEX DELETION OF MYELOID ANTIGENS CD33 AND CLL-1 BY CRISPR/CAS9 IN HUMAN HEMATOPOIETIC STEM CELLS HIGHLIGHTS THE POTENTIAL OF NEXT-GENERATION TRANSPLANTS FOR AML TREATMENT.

open access: yesHemaSphere, 2022
J. Xavier-Ferrucio   +22 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

ENHANCING COGNITION AND WORKING MEMORY THROUGH A MULTI-DIMENSIONAL DOPAMINERGIC N-BACK MEMORY GAME

open access: yesIBRO Neuroscience Reports, 2023
Sahar Jahanikia   +5 more
doaj   +1 more source

George Washington’s Attorneys: The Political Selection of United States Attorneys at the Founding [PDF]

open access: yes, 2019
This Article examines the relationship between the Nation’s first President and the selection of United States Attorneys. It argues that politics played an important, if not primary, role in the President’s selections.
Ingram, Scott
core   +1 more source

Innovative Mobility: Carsharing Outlook Carsharing Market Overview, Analysis, And Trends. [PDF]

open access: yes, 2020
Since 1998, 94 carsharing programs have been deployed in North America - 40 are operational and 52 are defunct. As of January 1, 2018, there were 18 active programs in Canada, 21 in the United States (U.S.), and one program in Mexico.
Cohen, Adam, Shaheen, Susan, PhD
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Remote operation of the DIII-D National Fusion Facility

open access: yesNuclear Fusion
Full remote scientific operation of the DIII-D National Fusion Facility is now possible through significant advances in the computer science hardware and software infrastructure made over the last decade.
D.P. Schissel   +17 more
doaj   +1 more source

Kebijakan Amerika Serikat terhadap Pengaruh Iran di Kawasan Amerika Latin pada Masa Pemerintahan Mahmoud Ahmadinejad Tahun 2009-2013 [PDF]

open access: yes, 2014
The aim of the research is to explain about the foreign policy of United States in countering Irans expansion in Latin America under Ahmadinejads administration in second term.
Altapia, L. (Lija)   +1 more
core  

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