Results 61 to 70 of about 911,909 (305)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

National Cyber Strategy of the United States of America

, 2018
With the release of this National Cyber Strategy, the United States now has its first fully articulated cyber strategy in 15 years. This strategy explains how the US will: Defend the homeland by protecting networks, systems, functions, and data; Promote ...
United States. White House Office.
core  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

89th Congress, 1st Session: Document No. 135

, 1965
Annual report submitted by the Girl Scouts of the United States of America to Congress describing highlights from 1964, activities, organizational leadership, and other information about scouting ...
Girl Scouts of the United States of America
core  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

1965 Annual Report. Girl Scouts of the U. S. A. 830 Third Avenue New York, N.Y. 10022

, 1966
Annual report submitted by the Girl Scouts of the United States of America to Congress describing highlights from 1965, activities, public relations, finance, organizational leadership, and other information about scouting ...
Girl Scouts of the United States of America
core  

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

review an article about “ fear and hope in Venezuela as U.S. warships lurk” in the new York  times magazine

قضايا سياسية
Venezuela has always been a small Rifle in Latin America, in addition to its diverse cultural heritage among peoples of multiple races and sects, including indigenous, latin , and African – Arab, and its richness with many natural resources, but all of ...
Majid Hameed Khdair
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

93rd Congress, 1st Session: Document No. 93-74

, 1973
Annual report submitted by the Girl Scouts of the United States of America to Congress describing highlights from 1972, activities, membership, finance, organizational leadership, and other information about scouting ...
Girl Scouts of the United States of America
core