Results 41 to 50 of about 777,892 (259)

A multicenter pragmatic implementation study of AI-ECG-based clinical decision support software to identify low LVEF: Clinical trial design and methods

open access: yesAmerican Heart Journal Plus
Background: Artificial intelligence (AI) enabled algorithms can detect or predict cardiovascular conditions using electrocardiogram (ECG) data. Clinical studies have evaluated ECG-AI algorithms, including a recent single-center study which evaluated ...
Francisco Lopez-Jimenez   +24 more
doaj   +1 more source

Dopuszczalność umownego kształtowania relacji prawno-rodzinnych na przykładzie kontaktów rodziców biologicznych z przysposobionym dzieckiem. Uwagi na tle prawno-porównawczym

open access: yesActa Iuris Stetinensis, 2017
The purpose of this publication is to analyze comparatively the Polish and American legal regulations concerning access to an adopted child by their biological parent.
Rafał Łukasiewicz
doaj   +1 more source

A cost comparison of atrial fibrillation monitoring strategies after embolic stroke of undetermined source

open access: yesAmerican Heart Journal Plus, 2022
Background: Detection of atrial fibrillation (AF) in patients with embolic stroke of undetermined source (ESUS) is challenging due to its paroxysmal nature.
Nagib Chalfoun   +18 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

« French belongs to no one, French belongs to everyone ». Sur l’attractivité de la littérature médiévale aux États-Unis

open access: yesPerspectives Médiévales, 2016
Academic positions as well as Master degrees in Medieval French language and literature have become more and more rare in The United States. It is therefore urgent to think of possible ways to stimulate the interest of students in order for them to take ...
Marion Uhlig
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

United States of America

open access: yesForum: Qualitative Social Research, 2000
As we stand poised to enter the next millennium there is perhaps no better opportunity to reflect on the beliefs, values and techniques that are shared and debated by qualitative researchers throughout the United States.
Bobbi A. Kerlin
doaj  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

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