Results 131 to 140 of about 3,464,691 (302)

Stellarator fusion systems enabled by arrays of planar coils

Nuclear Fusion
We present an overview of a novel electromagnetic coil configuration for stellarators and its application to two near-term fusion systems. The novel coil configuration is the planar coil stellarator, able to implement precisely-quasisymmetric 3D magnetic
D.A. Gates, S. Aslam, B. Berzin, P. Bonofiglo, A. Cote, D.W. Dudt, E. Flom, D. Fort, A. Koen, T.G. Kruger, S.T.A. Kumar, M.F. Martin, A. Ottaviano, S. Pasmann, P.K. Romano, C.P.S. Swanson, L. Tang, E. Winkler, R. Wu   +18 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The Latin American Consensus [PDF]

, 2007
Anti-Americanism has reached an unsettling global high that has been manifested in everything from opinion polls to violent protests. Latin America is geopolitically important to the United States, while harboring anti-American sentiment.
Miralrio, Amanda
core   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

NSTX-U research advancing the physics of spherical tokamaks

Nuclear Fusion
The objectives of NSTX-U research are to reinforce the advantages of STs while addressing the challenges. To extend confinement physics of low- A , high beta plasmas to lower collisionality levels, understanding of the transport mechanisms that set ...
J.W. Berkery, P.O. Adebayo-Ige, H. Al Khawaldeh, G. Avdeeva, S-G. Baek, S. Banerjee, K. Barada, D.J. Battaglia, R.E. Bell, E. Belli, E.V. Belova, N. Bertelli, N. Bisai, P.T. Bonoli, M.D. Boyer, J. Butt, J. Candy, C.S. Chang, C.F. Clauser, L.D. Corona Rivera, M. Curie, P.C. de Vries, R. Diab, A. Diallo, J. Dominski, V.N. Duarte, E.D. Emdee, N.M. Ferraro, R. Fitzpatrick, E.L. Foley, E. Fredrickson, M.E. Galante, K.F. Gan, S. Gerhardt, R. Goldston, W. Guttenfelder, R. Hager, M.O. Hanson, S.C. Jardin, T.G. Jenkins, S.M. Kaye, A. Khodak, J. Kinsey, A. Kleiner, E. Kolemen, S. Ku, M. Lampert, B. Leard, B.P. LeBlanc, J.B. Lestz, F.M. Levinton, C. Liu, T. Looby, R. Lunsford, T. Macwan, R. Maingi, J. McClenaghan, J.E. Menard, S. Munaretto, M. Ono, A. Pajares, J. Parisi, J-K. Park, M.S. Parsons, B.S. Patel, Y.V. Petrov, M. Podestà, F. Poli, M. Porcelli, T. Rafiq, S.A. Sabbagh, Á. Sánchez Villar, E. Schuster, J. Schwartz, A. Sharma, S. Shiraiwa, P. Sinha, D. Smith, S. Smith, V.A. Soukhanovskii, G. Staebler, E. Startsev, B. Stratton, K.E. Thome, W. Tierens, M. Tobin, I.U. Uzun-Kaymak, B. Van Compernolle, J. Wai, W. Wang, W. Wehner, A. Welander, J. Yang, V. Zamkovska, X. Zhang, X.L. Zhu, S. Zweben   +96 more
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source