Results 111 to 120 of about 5,695 (289)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Studies on the number theory of orders

, 1982
Bibliography: pages 78-81.In the nineteenth century no distinction was drawn between maximal and nonmaximal orders in a numberfield. Most of the work on orders in this period was done by Dedekind and Kronecker.
Omar, Mohammed Rafiq
core  

Unlimited lists of fundamental units of quadratic fields - Applications to some arithmetic properties: Units of norm −1, Norm equations, Non-p -rational fields, p-Class groups)

, 2023
Minor corrections and new numerical resultsWe use the polynomials m_s(t) = t^2 − 4s, s ∈ {−1, 1}, in an elementary process giving arbitrary large lists of fundamental units of quadratic fields of discriminants listed in ascending order.
Gras, Georges
core  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Discovering phone patterns in spoken utterances by non-negative matrix factorization

, 2008
We present a technique to automatically discover the (word-sized) phone patterns that are present in speech utterances. These patterns are learnt from a set of phone lattices generated from the utterances.
Stouten, Veronique, Demuynck, Kris, V. Stouten, Van hamme, Hugo, K. Demuynck, H. Van hamme   +5 more
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Matrix Factorization for Learning Metagenomic Pathways and Species

, 2015
This work considers learning meaningful sets of chemical reactions called pathways and groups of species called Operational Taxonomical Units (OTUs) from metagenomic data. The methods are based on Nonnegative Matrix Factorization (NMF).
Polvi-Huttunen, Silja
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Internal monotone-light factorization for categories via preorders

It is shown that, for a finitely-complete category C with coequalizers of kernel pairs, if every product-regular epi is also stably-regular then there exist the reflections (R)Grphs(C) → (R)Rel(C), from (reflexive) graphs into (reflexive) relations in C,
Xarez, J.J.
core  

Flexible control of motor units: is the multidimensionality of motor unit manifolds a sufficient condition?

Understanding flexibility in the neural control of movement requires identifying the distribution of common inputs to the motor units. In this study, we identified large samples of motor units from two lower limb muscles: the vastus lateralis (VL; up to ...
Logtens, Tijn, Cattagni, Thomas, Dernoncourt, Francois, Hug, Francois, Avrillon, Simon, Farina, Dario   +5 more
core   +1 more source