Results 71 to 80 of about 5,695 (289)

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Hierarchical Approach for Deriving a Reproducible LU factorization on GPUs

, 2016
International audienceWe propose a reproducible variant of the unblocked LU factorization for graphics processor units (GPUs). For this purpose, we provide Level-1/2 BLAS kernels that deliver correctly-rounded and reproducible results for the dot (inner)
Graillat, Stef, S, Iakymchuk, Roman, S, Quintana-Ortí, Enrique, S, Defour, David   +3 more
core  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

PDRs4All

Astronomy & Astrophysics
The Mid-Infrared Instrument (MIRI) is the imager and spectrograph covering wavelengths from 4.9 to 27.9 μm on board the James Webb Space Telescope (JWST).
Canin Amélie, Févotte Cédric, Dobigeon Nicolas, Van De Putte Dries, Onaka Takashi, Berné Olivier   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Gated Recurrent Unit-Based Deep Learning Framework for Personalized and Sequential Smart TV Content Recommendation

International Journal of Computational Intelligence Systems
With the rapid growth of smart TVs, the development of efficient recommendation systems has become essential to enhance the user experience. Most existing recommendation systems rely on collaborative filtering and matrix factorization techniques, which ...
Maragatharajan Muthusamy, Aanjankumar Sureshkumar, Rajesh Kumar Dhanaraj, Md Shohel Sayeed, Ahmad Alkhayyat, Nithya Rekha Sivakumar, Karthik Palani   +6 more
doaj   +1 more source

Lexical Sememe Prediction via Word Embeddings and Matrix Factorization

, 2017
Sememes are defined as the minimum semantic units of human languages. People have manually annotated lexical sememes for words and form linguistic knowledge bases.
Xingchi Yuan, Zhiyuan Liu, Maosong Sun, Ruobing Xie   +3 more
core   +1 more source