Results 91 to 100 of about 27,549 (267)

Perancangan Game First Person Shooter 3D “Zombie Hunter” dengan Menggunakan Metode A*

Journal of Information and Technology, 2017
Video Game adalah sebuah permainan dengan tampilan sebuah gambar atau visual yang dapat memberikan respon balik jika diberikan perintah-perintah tertentu menggunakan alat kontrol pada seperangkat sistem elektronik. Game First Person Shooter (FPS) adalah
Ryan Mahendra Kusuma Putra
doaj  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Creating Interactive Scenes in 3D Educational Games: Using Narrative and Technology to Explore History and Culture

Applied Sciences
Three-dimensional games are an indispensable tool in education and cultural transmission, offering users immersive experiences that facilitate learning through engagement and direct experience.
Rafał Kaźmierczak, Robert Skowroński, Cezary Kowalczyk, Grzegorz Grunwald   +3 more
doaj   +1 more source

Комп’ютерна гра на Unity 3D

, 2023
This bachelor thesis is devoted to the design and development of a computer game using Unity 3D. The purpose of the bachelor's qualification work is to improve the efficiency of technical design and development of games on Unity 3D. Objectives of the study: ● Study of the theoretical foundations of the gaming industry for designing computer games ...
openaire   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Connection of the SUMO Microscopic Traffic Simulator and the Unity 3D Game Engine to Evaluate V2X Communication-Based Systems. [PDF]

Sensors (Basel), 2018
Olaverri-Monreal C, Errea-Moreno J, Díaz-Álvarez A, Biurrun-Quel C, Serrano-Arriezu L, Kuba M.   +5 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Implementasi Teknik Visualisasi Dinamis pada Augmented Reality untuk Representasi Operasi Vektor

Techno.Com
Konsep vektor, khususnya terkait arah dan transformasi besaran dalam ruang 3D, menuntut kemampuan visualisasi spasial yang tinggi. Media pembelajaran konvensional dan aplikasi AR statis seringkali memiliki keterbatasan dalam merepresentasikan proses ...
Triana Harmini, Oddy Virgantara Putra, Hibatullah Agung Prihadian   +2 more
doaj   +1 more source