Results 91 to 100 of about 166,543,721 (283)

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Neonatal phototherapy and cancer risk: a systematic review and meta-analysis

Frontiers in Pediatrics
ObjectiveTo evaluate the risk of cancer after phototherapy for neonatal hyperbilirubinemia.Study designThis was a systematic review and meta-analysis. Electronic databases, including PubMed, Embase, and Cochrane Library, were searched.
Sloane J. Freeman, Sloane J. Freeman, Sloane J. Freeman, Charles D. G. Keown-Stoneman, Charles D. G. Keown-Stoneman, Charles D. G. Keown-Stoneman, Mariah Ghobrial, Thivia Jegathesan, Michael D. Sgro, Michael D. Sgro, Michael D. Sgro   +10 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Relations between the Conference of African Labour Ministers and the Organization of African Unity: Report of the Administrative Secretary-General. [PDF]

, 1974
Council of Ministers Twenty-Third Ordinary Session Mogadishu, June 1974.This report of the Administrative Secretary-General on the relationship between the conference of the African Labour Ministers and the Organizations of African Unity discussing the ...
Organization of African Unity
core   +1 more source

Understanding the role and organization of health workers delivering non-communicable disease management in primary care in low- and middle-income countries: a scoping review

BMC Primary Care
Background Non-communicable diseases are responsible for three-fourths of annual deaths worldwide and disproportionately affect individuals living in low- and middle-income countries.
Archna Gupta, Oluwasegun J. Ogundele, Roxana Rabet, Iryna Artyukh, Thiago Trindade, Doret Cheng, Daniel Osafo Darko, Mai Eltigany, Alarcos Cieza, Becky Skidmore, Katherine D. Rouleau   +10 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Validation of a standardised approach to collect sociodemographic and social needs data in Canadian primary care: cross-sectional study of the SPARK tool

BMJ Open
Objective This study validates the previously tested Screening for Poverty And Related social determinants to improve Knowledge of and access to resources (‘SPARK Tool’) against comparison questions from well-established national surveys (Post Survey ...
Kris Aubrey-Bassler, Alan Katz, Emily Gard Marshall, Itunuoluwa Adekoya, Nazeem Muhajarine, Andrew David Pinto, Alannah Delahunty-Pike, Dana Howse, Leanne Kosowan, Abigail Zita Seshie, Eunice Abaga, Jane Cooney, Marjeiry Robinson, Dorothy Senior, Alexander Zsager, Joseph J O’Rourke, Cory Neudorf, Mandi Irwin   +17 more
doaj   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Introducción a Unity

, 2018
En este OVA se introduce el concepto de Unity como motor de desarrollo de videojuegos. Adicionalmente se explican las ventajas y desventajas de este entorno de desarrollo y por medio de un video se explican los diferentes páneles que conforman el entorno
Jorge Luis Bacca Acosta, Bacca Acosta, Jorge Luis   +1 more
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