Results 101 to 110 of about 71,038 (298)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Contributions to the study and modeling of knowledge development systems [PDF]

, 2008
Not ...
Penubothu, Maruti
core  

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Neonatal phototherapy and cancer risk: a systematic review and meta-analysis

Frontiers in Pediatrics
ObjectiveTo evaluate the risk of cancer after phototherapy for neonatal hyperbilirubinemia.Study designThis was a systematic review and meta-analysis. Electronic databases, including PubMed, Embase, and Cochrane Library, were searched.
Sloane J. Freeman, Sloane J. Freeman, Sloane J. Freeman, Charles D. G. Keown-Stoneman, Charles D. G. Keown-Stoneman, Charles D. G. Keown-Stoneman, Mariah Ghobrial, Thivia Jegathesan, Michael D. Sgro, Michael D. Sgro, Michael D. Sgro   +10 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

One giant leap. Review of: Consilience: the Unity of Knowledge by Edward O. Wilson [PDF]

, 1999
Book review of Consilience: The Unity of Knowledge. Edward O. Wilson.
Costanza, Robert
core   +1 more source

Understanding the role and organization of health workers delivering non-communicable disease management in primary care in low- and middle-income countries: a scoping review

BMC Primary Care
Background Non-communicable diseases are responsible for three-fourths of annual deaths worldwide and disproportionately affect individuals living in low- and middle-income countries.
Archna Gupta, Oluwasegun J. Ogundele, Roxana Rabet, Iryna Artyukh, Thiago Trindade, Doret Cheng, Daniel Osafo Darko, Mai Eltigany, Alarcos Cieza, Becky Skidmore, Katherine D. Rouleau   +10 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Validation of a standardised approach to collect sociodemographic and social needs data in Canadian primary care: cross-sectional study of the SPARK tool

BMJ Open
Objective This study validates the previously tested Screening for Poverty And Related social determinants to improve Knowledge of and access to resources (‘SPARK Tool’) against comparison questions from well-established national surveys (Post Survey ...
Kris Aubrey-Bassler, Alan Katz, Emily Gard Marshall, Itunuoluwa Adekoya, Nazeem Muhajarine, Andrew David Pinto, Alannah Delahunty-Pike, Dana Howse, Leanne Kosowan, Abigail Zita Seshie, Eunice Abaga, Jane Cooney, Marjeiry Robinson, Dorothy Senior, Alexander Zsager, Joseph J O’Rourke, Cory Neudorf, Mandi Irwin   +17 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source