Results 81 to 90 of about 1,991,944 (311)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
, 1878 Contén: La española inglesa ; El celoso estremeñoPrecede ó tit.: Nueva publicación de lujoLa gitanilla ; El amante liberal ; Rinconete y cortadillo ; La española inglesa ; El licenciado vidriera ; La fuerza de la sangre ; El celoso extremeño ; La ilustre
Cervantes Saavedra, Miguel de, 1547-1616
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, 2001 Esta obra traza un recorrido completo por los distintos factores y elementos que se conjugan en los puestos de trabajo de oficinas y despachos y que pueden tener una repercusión directa en la salud de quienes ocupan dichos puestos.
Gómez Fernández, Miguel A. +3 more
core +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
How “Universal” are Universal Precautions?
AMA Journal of Ethics, 2009 Guidelines to improve observance of universal precaution standards and reporting of needlestick injuries by medical students and resident physicians. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire +2 more sources
Discurso pronunciado por Ramón Prida en la Academia Mexicana de Jurisprudencia
, 1897 42 p.
Prida, Ramón
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Molecular Oncology, EarlyView.Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley +1 more source