Results 71 to 80 of about 1,576,879 (317)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

A Survey of Approximation Algorithms for the Universal Facility Location Problem

open access: yesMathematics
The facility location problem is a classical combinatorial optimization problem with extensive applications spanning communication technology, economic management, traffic governance, and public services.
Hanyin Xiao   +3 more
doaj   +1 more source

Título: El Celoso estremeño

open access: yes, 1878
Contén: La española inglesa ; El celoso estremeñoPrecede ó tit.: Nueva publicación de lujoLa gitanilla ; El amante liberal ; Rinconete y cortadillo ; La española inglesa ; El licenciado vidriera ; La fuerza de la sangre ; El celoso extremeño ; La ilustre
Cervantes Saavedra, Miguel de, 1547-1616
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Universal digital mental health interventions for children and youth: a scoping review

open access: yesFrontiers in Digital Health
IntroductionDigital mental health interventions (DMHIs) are increasingly used to support child and youth mental health, yet the scope and characteristics of universal (Tier 1) DMHIs remain poorly defined.MethodsThis scoping review synthesized peer ...
Kaitlin Di Pierdomenico   +6 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

Introduction

open access: yesMiranda: Revue Pluridisciplinaire du Monde Anglophone
In his recent book Universaliser: Pour un dialogue des cultures (2024), Souleymane Bachir Diagne invites us to “reinvent the universal” (Daigne 11-26) by considering it in relation to the “plural of the world” (116).
Caroline Pollentier   +3 more
doaj   +1 more source

Map of the Hannan's goldfield, West Australia [cartographic material].

open access: yes, 1898
Map of goldfield near Kalgoorlie showing leases, shafts, batteries, telegraph and tramway lines and pipeline.; Inset: Map of Western Australia.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.map ...
Universal Publishing Co.
core  

Home - About - Disclaimer - Privacy