Results 71 to 80 of about 1,991,944 (311)
Making Universal Policies Universal
International Joint Conference on Autonomous Agents and Multiagent SystemsThe development of a generalist agent capable of solving a wide range of sequential decision-making tasks remains a significant challenge. We address this problem in a cross-agent setup where agents share the same observation space but differ in their action spaces.
Hoepner, Niklas +2 more
openaire +3 more sources
Learning at the University - conceptions of university teachers
, 2020 Academia, No 22 (2021)
Chaleta, Elisa, Saraiva, Margarida
openaire +4 more sources
Universal Service League, New South Wales Branch.
, 1915 Caption title; Also available online http://nla.gov.au/nla.aus-vn1990306; FERG copy from Ferguson First World War, 1914-1919 pamphlet ...
Universal Service League (Sydney, N.S.W.)
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Map of the Hannan's goldfield, West Australia [cartographic material].
, 1898 Map of goldfield near Kalgoorlie showing leases, shafts, batteries, telegraph and tramway lines and pipeline.; Inset: Map of Western Australia.; Also available in an electronic version via the Internet at: http://nla.gov.au/nla.map ...
Universal Publishing Co.
core