Results 91 to 100 of about 1,569,596 (297)
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source
Universal aspects of high-temperature relaxation dynamics in random spin models
SciPost PhysicsUniversality is a crucial concept in modern physics, allowing us to capture the essential features of a system's behavior using a small set of parameters.
Tian-Gang Zhou, Wei Zheng, Pengfei Zhang
doaj +1 more source
Signal-noise ratio of adaptive geophysical studies
Геофизический журнал, 2014 Spectrum of signal-noise ratio is a conclusive and ultimate factor of adaptive technology of geo-physical and particularly seismic studies and thereafter it is specialized example of universal twofold deterministic-stochastic index of adaptive ...
V. I. Roman
doaj +1 more source
Universal Function Approximation on Graphs
, 2020 In this work we produce a framework for constructing universal function approximators on graph isomorphism classes. We prove how this framework comes with a collection of theoretically desirable properties and enables novel analysis. We show how this allows us to achieve state-of-the-art performance on four different well-known datasets in graph ...
openaire +3 more sources
Adenosine triphosphate as a modulator of protein interactions and stability
FEBS Open Bio, EarlyView.ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley +1 more source
Universal approximation property of stochastic configuration networks for time series
Industrial Artificial IntelligenceFor the purpose of processing sequential data, such as time series, and addressing the challenge of manually tuning the architecture of traditional recurrent neural networks (RNNs), this paper introduces a novel approach-the Recurrent Stochastic ...
Jin-Xi Zhang, Hangyi Zhao, Xuefeng Zhang
doaj +1 more source
Protocol for quantifying miRNA trafficking across the endosomal membrane
FEBS Open Bio, EarlyView.An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh +2 more
wiley +1 more source
Nuclear Physics B, 2016 We derive an exact formula for the stochastic evolution of the characteristic determinant of a class of deformed Wishart matrices following from a chiral random matrix model of QCD at finite chemical potential.
Yizhuang Liu +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti +5 more
wiley +1 more source