Results 51 to 60 of about 816 (272)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Security Proof of Single-Source Shortest Distance Protocols Built on Secure Multiparty Computation Protocols

Cryptography
Secure secret-sharing Single-Source Shortest Distance (SSSD) protocols, based on secure multiparty computation (SMC), offer a promising solution for securely distributing and managing sensitive information among multiple parties. However, formal security
Mohammad Anagreh, Peeter Laud
doaj   +1 more source

Composing security protocols: from confidentiality to privacy [PDF]

, 2015
Security protocols are used in many of our daily-life applications, and our privacy largely depends on their design. Formal verification techniques have proved their usefulness to analyse these protocols, but they become so complex that modular ...
Arapinis, Myrto, Arapinis, Myrto; id_orcid, Stéphanie Delaune, Myrto Arapinis, Cheval, Vincent, Delaune, Stéphanie, Vincent Cheval   +6 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The IITM Model: a Simple and Expressive Model for Universal Composability [PDF]

, 2018
The universal composability paradigm allows for the modular design and analysis of cryptographic protocols. It has been widely and successfully used in cryptography. However, devising a coherent yet simple and expressive model for universal composability
Max Tuengerthal, Daniel Rausch, Ralf Kuesters   +2 more
core  

Universal Composition with Responsive Environments [PDF]

, 2016
In universal composability frameworks, adversaries (or environments) and protocols/ideal functionalities often have to exchange meta-information on the network interface, such as algorithms, keys, signatures, ciphertexts, signaling information, and ...
Daniel Rausch, Jan Camenisch, Stephan Krenn, Robert R. Enderlein, Ralf Kuesters, Ralf Küsters, Robert R. Enderlein   +6 more
core   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Mechanized Proofs of Adversarial Complexity and Application to Universal Composability: Journal pre-print: full version

, 2023
Journal pre-print: full versionInternational audienceIn this paper we enhance the EasyCrypt proof assistant to reason about computational complexity of ad-versaries.
Barbosa, Manuel, Barthe, Gilles, Adrien Koutsos, Grégoire, Benjamin, Pierre-Yves Strub, Koutsos, Adrien, Manuel Barbosa, Gilles Barthe, Benjamin Grégoire, Strub, Pierre-Yves   +9 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Universally Composable Traceable Ring Signature with Verifiable Random Function in Logarithmic Size

Cryptography
Traceable ring signatures (TRSs) allow a signer to create a signature that maintains anonymity while enabling traceability if needed. It merges the characteristics of traditional ring signatures with the ability to trace signers, making it ideal for ...
Kwan Yin Chan, Tsz Hon Yuen, Siu Ming Yiu   +2 more
doaj   +1 more source