Results 51 to 60 of about 959,083 (268)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Universally Composable Traceable Ring Signature with Verifiable Random Function in Logarithmic Size

Cryptography
Traceable ring signatures (TRSs) allow a signer to create a signature that maintains anonymity while enabling traceability if needed. It merges the characteristics of traditional ring signatures with the ability to trace signers, making it ideal for ...
Kwan Yin Chan, Tsz Hon Yuen, Siu Ming Yiu   +2 more
doaj   +1 more source

Universally Composable Adaptive Oblivious Transfer [PDF]

, 2008
In an oblivious transfer (OT) protocol, a Sender with messages M 1 ,...,M N and a Receiver with indices *** 1 ,...,*** k *** [1,N ] interact in such a way that at the end the Receiver obtains $M_{\sigma_1},\dots,M_{\sigma_k}$ without learning anything about the other messages and the Sender does not learn anything about *** 1 ,...,***
Matthew Green 0001, Susan Hohenberger
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Temporal composability

, 2002
The constructive design of dependable distributed real-time systems out of prevalidated components requires precise interface specifications of the components in the temporal domain and in the value domain.
Obermaisser, Roman, Kopetz, Hermann
core   +4 more sources

A Survey of Post-Quantum Oblivious Protocols

Cryptography
Modern distributed computing systems and applications with strict privacy requirements demand robust data confidentiality. A primary challenge involves enabling parties to exchange data or perform joint computations.
Altana Khutsaeva, Anton Leevik, Sergey Bezzateev   +2 more
doaj   +1 more source

Universally Composable Security with Global Setup [PDF]

, 2007
Cryptographic protocols are often designed and analyzed under some trusted set-up assumptions, namely in settings where the participants have access to global information that is trusted to have some basic security properties. However, current modeling of security in the presence of such set-up falls short of providing the expected security guarantees.
Ran Canetti, Yevgeniy Dodis, Rafael Pass, Shabsi Walfish   +3 more
openaire   +2 more sources