Results 61 to 70 of about 816 (272)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A Survey of Post-Quantum Oblivious Protocols

Cryptography
Modern distributed computing systems and applications with strict privacy requirements demand robust data confidentiality. A primary challenge involves enabling parties to exchange data or perform joint computations.
Altana Khutsaeva, Anton Leevik, Sergey Bezzateev   +2 more
doaj   +1 more source

Simulatable Security and Polynomially Bounded Concurrent Composability

, 2006
Simulatable security is a security notion for multi-party protocols that implies strong composability features. The main definitional flavours of simulatable security are standard simulatability, universal simulatability, and black-box simulatability ...
D. Hofheinz, Hofheinz, Dennis, Dominique Unruh, Unruh, Dominique, Hofheinz, D. (Dennis), Dennis Hofheinz, D. Unruh, Unruh, D.   +7 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

GNUC: A New Universal Composability Framework [PDF]

, 2012
We put forward a framework for the modular design and analysis of multi-party protocols. Our framework is called ``GNUC\u27\u27 (with the recursive meaning ``GNUC\u27s Not UC\u27\u27), already alluding to the similarity to Canetti\u27s Universal ...
Victor Shoup, Dennis Hofheinz
core  

A Universally Composable Mix-Net [PDF]

, 2004
A mix-net is a cryptographic protocol executed by a set of mix-servers that provides anonymity for a group of senders. The main application is electronic voting.
openaire   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Universally Composable Adaptive Oblivious Transfer [PDF]

, 2008
In an oblivious transfer (OT) protocol, a Sender with messages M 1 ,...,M N and a Receiver with indices *** 1 ,...,*** k *** [1,N ] interact in such a way that at the end the Receiver obtains $M_{\sigma_1},\dots,M_{\sigma_k}$ without learning anything about the other messages and the Sender does not learn anything about *** 1 ,...,***
Matthew Green 0001, Susan Hohenberger
openaire   +2 more sources