Results 41 to 50 of about 538,768 (298)
Existential Design Applied in Universal Design Settings [PDF]
, 2016 : The critical design method aims to discuss ways of opening up the (design) brief when planning, designing, building, operating and maintaining the future of the built environment – public as well as private, indoor as well as outdoor.
Torkildsby, Anne Britt
core +1 more source
The Concepts of Accessibility and Equality in Design Education: The Universal Design Approach
Iconarp International Journal of Architecture and Planning, 2014 Universal design approach aims to design products and environments that provide equal access for everyone to the variety of activities. Universal design applications and research and discussions related to these applications can be seen in different ...
Guliz Mugan Akıncı
doaj +2 more sources
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Beyond the Buzzword: Unpacking ‘Special Needs’ in Denmark
Scandinavian Journal of Disability ResearchThe term ‘special needs’ encompasses various definitions of what is considered ‘special’ for children with functional variations. These definitions reflect societal views shaped by politics, economics, governance, and knowledge, all of which ...
Pia Ringø, Emil Søbjerg Falster
doaj +1 more source
Journal of Architectural Sciences and Applications, 2021 With the changing and developing conditions, people's expectations from the places have also been affected and the concept of 'accessibility' has gained more importance. Structures whose user is everyone must meet the needs of users.
İrem Bekar
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Universal Design Learning (UDL) for Extension Audiences
EDISUniversal Design Learning (UDL) is about designing for the minority in the learning environment to meet the needs of all. This publication explains the principles of Universal Design Learning—engagement, representation, and action and expression—and how
Vanessa Spero
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source