Results 41 to 50 of about 2,173,605 (280)

The idea of universal design at the university - the context of the development of students with disabilities.

open access: yesJournal of Modern Science, 2023
Objectives Presenting the idea of universal design in higher education and indicate that the appropriate adaptation of teaching conditions to the potential of learners is the basic context for the development of their competences.
Mateusz Barłóg, Anna Sadowska
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Accessibility of Tourism Space from a Geographical Perspective [PDF]

open access: yes, 2014
The accessibility of tourism space is becoming an increasingly significant issue in geographical research due to, amongst other things, demographic changes (an ageing population, growing numbers of people with disabilities) alongside guaranteeing a ...
Zajadacz, Alina
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Beyond the Buzzword: Unpacking ‘Special Needs’ in Denmark

open access: yesScandinavian Journal of Disability Research
The term ‘special needs’ encompasses various definitions of what is considered ‘special’ for children with functional variations. These definitions reflect societal views shaped by politics, economics, governance, and knowledge, all of which ...
Pia Ringø, Emil Søbjerg Falster
doaj   +1 more source

Evaluation of Library Interior Spaces Within the Context of Universal Design Principles: Karadeniz Technical University Faik Ahmet Barutcu Library

open access: yesJournal of Architectural Sciences and Applications, 2021
With the changing and developing conditions, people's expectations from the places have also been affected and the concept of 'accessibility' has gained more importance. Structures whose user is everyone must meet the needs of users.
İrem Bekar
doaj   +1 more source

Designing Cyclic Universe Models [PDF]

open access: yesPhysical Review Letters, 2004
Recent advances in understanding the propagation of perturbations through the transition from big crunch to big bang (esp. Tolley et al. hep-th/0306109) make it possible for the first time to consider the full set of phenomenological constraints on the scalar field potential in cyclic models of the universe.
Khoury, Justin   +2 more
openaire   +3 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

General impossible operations in quantum information

open access: yes, 2002
We prove a general limitation in quantum information that unifies the impossibility principles such as no-cloning and no-anticloning. Further, we show that for an unknown qubit one cannot design a universal Hadamard gate for creating equal superposition ...
A.K. Pati   +24 more
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

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