Results 61 to 70 of about 483,833 (252)

Designed to deter: Barriers to facilities at secondary schools in Ghana

African Journal of Disability, 2012
Background: There are varied and complex problems associated with the admission of students with disabilities into secondary (senior high) schools all over the world.
Anthony K. Danso, Frances E. Owusu-Ansah, Divine Alorwu   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Bridging multisensory and ud towards compassionate design in Malaysia interior design industry

ARTEKS : Jurnal Teknik Arsitektur
In the field of interior design, creating inclusive and engaging spaces is crucial. Universal Design (UD) and multisensory are supportive approaches that can work together to achieve this, however there is a lack of studies on the importance of universal
Jia Yi Choy, Muhammad Firzan Abdul Aziz
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Determining the Innovativeness of Nurses Who Engage in Activities That Encourage Innovative Behaviors

Nursing Reports
Background: We sought to understand the innovativeness of nurses engaging in innovative behaviors and quantify the associated characteristics that make nurses more able to innovate in practice.
Marion Leary, George Demiris, J. Margo Brooks Carthon, Pamela Z. Cacchione, Subhash Aryal, Jose A. Bauermeister   +5 more
doaj   +1 more source

MODERN PROBLEMS OF THE COURSE OF “TECHNOLOGY FOR THE DECORATIVE PROCESSING OF MATERIALS”

Российский технологический журнал, 2017
The paper analyzes development of the "Technology for the decorative processing of materials" course for students. The course was created in 1992 in order to train personnel competent both in the field of design and in that of materials science.
M. L. Sokolova
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

From Universal Precautions to Universal Design: Disclosure of Concealable Disability in the Case of HIV

Journal of Moral Theology, 2017
Viewing HIV through a theology of disability lens highlights the need to overcome the stigma that leaves persons and their caregivers excluded from Christian community and other aspects of social life.
Mary M. Doyle Roche
doaj  

Unlocking Brilliance: A Smart Approach to Icon Colour Design Inspired by Universal Design Principles

Buildings
Icons are integral to the signature systems within architectural spaces, serving pivotal roles through human–environment interactions. However, previous icon designs often exhibited a considerable randomness and neglected the needs of visually impaired ...
Erke Zhang, Zhexi Yang, Wei Zhao, Zihan Mei, Yuanyuan Xia, Fei Chen   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source