Results 61 to 70 of about 2,173,605 (280)
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Towards eXtended Universal Design
, 2022 Even though eXtended Reality (XR) technology has been trialed in various projects in primary and secondary education, its lack of universal design hinders further adoption. In this paper, we present the results from focus group interviews with representatives from Norway’s private and public sectors, in which we investigated their practical experiences
Joschua Thomas, Simon-Liedtke +1 more
openaire +2 more sources
NKCC1: A key regulator of glioblastoma progression
Molecular Oncology, EarlyView.Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen +5 more
wiley +1 more source
ENSURING THE INDEPENDENT LIFE OF PEOPLE WITH DISABILITIES IN A REGIONAL SOCIETY
Вестник университета, 2018 Ensuring the independent life of people with disabilities has been determined by the state of many factors, among which the availability of social infrastructure is crucial.
G. Zhigunova
doaj +1 more source
Digital Barriers: Making Technology Work for People [PDF]
, 2010 This paper was originally given as an oral presentation at the ‘3rd International Conference for Universal Design’, International Association for Universal Design, Hamamatsu, Japan (2010) and subsequently published.
Bichard, Jo-Anne, Gheerawo, Rama
core
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
UNIVERSAL DESIGN APPLICATION THROUGH SOUTH KOREA REDEVELOPMENT (A Study Review) [PDF]
, 2016 The evolution toward Universal Design was began in the 1950s with a new attention to design for people with disabilities. At the same era South Korea began their development after several wars. Recently some of researchs and projects in South Korea which
HARSRITANTO, Bangun Indrakusumo R
core
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source
Internet Access by People with Intellectual Disabilities: Inequalities and Opportunities
Future Internet, 2013 This review gives an overview of the societal inequalities faced by people with intellectual disabilities, before focusing specifically on challenges people face accessing the Internet. Current access will be outlined along with the societal, support and
Chris Fullwood +2 more
doaj +1 more source
Journal of Architectural Sciences and Applications, 2020 Kent parklarının planlama ve tasarımlarının evrenselliği büyük önem taşımaktadır. Bu çalışma kent parklarının kullanımında insanların karşılaştığı sorunların altını çizmeyi ve bu sorunlara evrensel planlama ve tasarım bağlamında çözüm sunmayı ...
Mustafa Seçme, Volkan Küçük
doaj +1 more source