Results 61 to 70 of about 538,768 (298)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Universal health plan proposal
, 2022 Title from PDF caption (viewed on September 14, 2022)."The Joint Task Force on Universal Care began with the passing of Senate Bill 770. The task is to design a universal health plan that would be equitable, affordable, and comprehensive. This plan would
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Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
A culture of universal empathy in design at the south east technological university carlow.
, 2015 This paper discusses the development of a culture of ‘Universal Empathy’ within Product Design programmes at the Institute of Technology Carlow. The concept draws from the inclusive, holistic nature of Universal Design and its principles together with ...
White, P.J., Dempsey, Hilary
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Internet Access by People with Intellectual Disabilities: Inequalities and Opportunities
Future Internet, 2013 This review gives an overview of the societal inequalities faced by people with intellectual disabilities, before focusing specifically on challenges people face accessing the Internet. Current access will be outlined along with the societal, support and
Chris Fullwood +2 more
doaj +1 more source
Journal of Architectural Sciences and Applications, 2020 Kent parklarının planlama ve tasarımlarının evrenselliği büyük önem taşımaktadır. Bu çalışma kent parklarının kullanımında insanların karşılaştığı sorunların altını çizmeyi ve bu sorunlara evrensel planlama ve tasarım bağlamında çözüm sunmayı ...
Mustafa Seçme, Volkan Küçük
doaj +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Designers and manufacturers’ perspectives on inclusive/universal design
, 2003 Inclusive design in the U.K. and its U.S. counterpart, universal design, present opportunities and challenges to industry. In order to encourage manufacturers and design companies to adopt more inclusive design practices, the research has been carried ...
Keates, S. +5 more
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FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Inclusive universal design practice and activism : a case study
, 2010 This paper reports on a unique approach to inclusive practice that responds to several critical issues highlighted in the first Universal Design (UD) Conference in Yokohama as well as in more recent literature on universal design.
Hannaford, Robert +4 more
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