Results 51 to 60 of about 483,833 (252)
Journal of Architectural Sciences and Applications, 2020 Kent parklarının planlama ve tasarımlarının evrenselliği büyük önem taşımaktadır. Bu çalışma kent parklarının kullanımında insanların karşılaştığı sorunların altını çizmeyi ve bu sorunlara evrensel planlama ve tasarım bağlamında çözüm sunmayı ...
Mustafa Seçme, Volkan Küçük
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Eigenpolytope Universality and Graphical Designs
SIAM Journal on Discrete Mathematics18 pages, 8 figures, 1 ...
Catherine Babecki, David Shiroma
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
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Implementation of Universal Design Concept on Lecture Space for Students with Hearing Disabilities
Indonesian Journal of Disability Studies, 2019 Campus building is where students undergo of learning process and perform various activities. In learning process, campus should provide universal design facilities for students all, including students with disabilities.
Rachmita Maun Harahap +3 more
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Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Towards Universal Accessibility: Architectural Barriers in Ukhrul, a Hilly District of Manipur
Indian Journal of Physical Medicine & RehabilitationIntroduction: Architectural barriers significantly impede access and mobility, especially for persons with disabilities (PWDs). Rural areas like Ukhrul, a hilly district in Manipur, face unique challenges in creating accessible environments due to their ...
S. U. Priyanka +5 more
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