Results 61 to 70 of about 2,160,399 (278)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Weighted universal image compression [PDF]

, 1999
We describe a general coding strategy leading to a family of universal image compression systems designed to give good performance in applications where the statistics of the source to be compressed are not available at design time or vary over time or ...
Chou, Philip A., Effros, Michelle, Gray, Robert M.   +2 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Towards eXtended Universal Design

, 2022
Even though eXtended Reality (XR) technology has been trialed in various projects in primary and secondary education, its lack of universal design hinders further adoption. In this paper, we present the results from focus group interviews with representatives from Norway’s private and public sectors, in which we investigated their practical experiences
Joschua Thomas, Simon-Liedtke, Rigmor, Baraas   +1 more
openaire   +2 more sources

Fundamental Researches for Education Curricula of Universal Design (Part1); Constitution of Universal Design and Problem of Universal Design in the School Education [PDF]

, 2014
　本研究では，ユニバーサルデザインを基軸にした題材によって，小学校から高等学校にか けて長期的な学びのカリキュラム構築をめざしている。研究をすすめるにあたり，教員およ び児童・生徒の，生活におけるユニバーサルデザインの認識の違いが課題となる。本稿では， すべての人のため，もしくは障害者のためとの考えが大きい中，より広義な意味で社会や自 然，個人を考える教育活動をめざすため，研究の基盤となるユニバーサルデザインの考え方 をまとめるべく，歴史背景や現在の社会の状況 ...
Kiyota, Tetsuo
core   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

ENSURING THE INDEPENDENT LIFE OF PEOPLE WITH DISABILITIES IN A REGIONAL SOCIETY

Вестник университета, 2018
Ensuring the independent life of people with disabilities has been determined by the state of many factors, among which the availability of social infrastructure is crucial.
G. Zhigunova
doaj   +1 more source

Digital Barriers: Making Technology Work for People [PDF]

, 2010
This paper was originally given as an oral presentation at the ‘3rd International Conference for Universal Design’, International Association for Universal Design, Hamamatsu, Japan (2010) and subsequently published.
Bichard, Jo-Anne, Gheerawo, Rama
core  

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source