Results 61 to 70 of about 2,166,456 (328)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

NOSQL design for analytical workloads: Variability matters [PDF]

open access: yes, 2016
Big Data has recently gained popularity and has strongly questioned relational databases as universal storage systems, especially in the presence of analytical workloads.
Abelló Gamazo, Alberto   +2 more
core   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

On the Design of Universal LDPC Codes

open access: yes, 2008
Low-density parity-check (LDPC) coding for a multitude of equal-capacity channels is studied. First, based on numerous observations, a conjecture is stated that when the belief propagation decoder converges on a set of equal-capacity channels, it would ...
Ardakani, Masoud   +2 more
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Internet Access by People with Intellectual Disabilities: Inequalities and Opportunities

open access: yesFuture Internet, 2013
This review gives an overview of the societal inequalities faced by people with intellectual disabilities, before focusing specifically on challenges people face accessing the Internet. Current access will be outlined along with the societal, support and
Chris Fullwood   +2 more
doaj   +1 more source

Denizli Vali Recep Yazıcıoğlu (İncilipınar) Parkı Evrensel Tasarım ve Planlama Bağlamında Değerlendirilmesi

open access: yesJournal of Architectural Sciences and Applications, 2020
Kent parklarının planlama ve tasarımlarının evrenselliği büyük önem taşımaktadır. Bu çalışma kent parklarının kullanımında insanların karşılaştığı sorunların altını çizmeyi ve bu sorunlara evrensel planlama ve tasarım bağlamında çözüm sunmayı ...
Mustafa Seçme, Volkan Küçük
doaj   +1 more source

Towards eXtended Universal Design

open access: yes, 2022
Even though eXtended Reality (XR) technology has been trialed in various projects in primary and secondary education, its lack of universal design hinders further adoption. In this paper, we present the results from focus group interviews with representatives from Norway’s private and public sectors, in which we investigated their practical experiences
Joschua Thomas, Simon-Liedtke   +1 more
openaire   +2 more sources

Digital Barriers: Making Technology Work for People [PDF]

open access: yes, 2010
This paper was originally given as an oral presentation at the ‘3rd International Conference for Universal Design’, International Association for Universal Design, Hamamatsu, Japan (2010) and subsequently published.
Bichard, Jo-Anne, Gheerawo, Rama
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

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