Results 221 to 230 of about 1,366,602 (255)

How Bioethicists Can Contribute to Democratic Deliberation

Bioethics, EarlyView.
ABSTRACT It is sometimes suggested that policymaking on bioethical questions should be more democratic, either through direct popular participation (as in a referendum) or through improved forms of representation (such as random mini‐publics or elected officials). Such proposals seem to leave no special place for input from bioethicists.
Ben Saunders
wiley   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Elimination of HPV-associated cancers: universal HPV vaccination and the role of anal screening - a meeting report. [PDF]

BMC Proc
Burdier FR, Bruni L, Giuliano AR, Mugo NR, Roy K, Palefsky JM, Burchell AN, Roelandt P, Baay M, Man I, Baussano I, Waheed DE, Vorsters A.   +12 more
europepmc   +1 more source

Advances in Spatial Heterogeneity and Cellular Localization Specificity of Intratumoral Bacteria

Cancer Science, EarlyView.
Spatial localization of intratumoral bacteria governs their functional roles in tumor progression, metastasis, and treatment responses, with guiding significance for clinical management, as reviewed across three spatial paradigms. ABSTRACT Bacteria in tumors are increasingly recognized to be a part of the tumor microenvironment and their biological ...
Minlan Ren, Jing Jia, Tingting Li, Yiwei Li, Nanxiang Shen, Yun Shi, Zhe Wang, Hao Fan, Guangli Sun, Guanying Xiong, Gang Li, Rui Peng   +11 more
wiley   +1 more source

Past and Present Vaccinations in Sweden

Acta Paediatrica, EarlyView.
Sven Arne Silfverdal
wiley   +1 more source

From Control to Elimination: Making the End of Dental Caries Thinkable

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Background Dental caries remains one of the most prevalent noncommunicable diseases worldwide despite decades of clinical and behavioural interventions. Persistently high prevalence suggests that current approaches are better organised for ongoing disease management than for preventing new disease occurrence.
Habib Benzian, Manu Raj Mathur, Eugenio Beltrán‐Aguilar   +2 more
wiley   +1 more source

Olfactory Tuft Cells Are Critical to Basal Inflammation, Innate Immune Response to Viral Infection, and Modulation of Quiescent Stem Cell Activation, Proliferation and Differentiation

Cell Proliferation, EarlyView.
Olfactory tuft cells communicate with other mucosal cells in maintaining olfactory epithelial immunity and sensory function. Disruption of tuft cell signalling pathways causes a skewed immune response, leading to heightened inflammation and increased activation of the quiescent stem cells, which are further exacerbated by viral infection.
Sai‐Sai Zhang, Haiyan Wang, Yi‐Sen Yang, Yi‐Hong Li, Defu Yu, Yushi Yao, Ruhong Zhou, Liquan Huang   +7 more
wiley   +1 more source

Impact of Removing the Universal Hepatitis B Birth-Dose Vaccination in the US. [PDF]

JAMA Pediatr
Lind ML, Hitchings MDT, Singh RP, Linas BP, Cummings DAT, Epstein RL.   +5 more
europepmc   +1 more source

Frontline Healthcare Professionals' Perceptions of the Duty to Care During the COVID‐19 Pandemic: A Multi‐Method Study in Mozambique

Developing World Bioethics, EarlyView.
ABSTRACT COVID‐19 intensified ethical tensions between clinicians' duty to care and self‐protection amid PPE shortages. We explored frontline healthcare professionals' perspectives in Maputo, Mozambique. Semi‐structured interviews with healthcare professionals at four hospitals (April–June 2022) were recorded in Portuguese, transcribed, and ...
Ângela Alface, Graça Salomé, Khátia Munguambe, Troy D. Moon, Esperança Sevene, Elizabeth Heitman   +5 more
wiley   +1 more source