Results 51 to 60 of about 1,366,602 (255)

The Hurdles From Bench to Bedside in the Realization and Implementation of a Universal Influenza Vaccine

Frontiers in Immunology, 2018
Influenza viruses circulate worldwide causing annual epidemics that have a substantial impact on public health. This is despite vaccines being in use for over 70 years and currently being administered to around 500 million people each year.
Sophie A. Valkenburg, Sophie A. Valkenburg, Nancy H. L. Leung, Maireid B. Bull, Maireid B. Bull, Li-meng Yan, Athena P. Y. Li, Athena P. Y. Li, Leo L. M. Poon, Benjamin J. Cowling   +9 more
doaj   +1 more source

Antibody Focusing to Conserved Sites of Vulnerability: The Immunological Pathways for ‘Universal’ Influenza Vaccines

Vaccines, 2021
Influenza virus remains a serious public health burden due to ongoing viral evolution. Vaccination remains the best measure of prophylaxis, yet current seasonal vaccines elicit strain-specific neutralizing responses that favor the hypervariable epitopes ...
Maya Sangesland, Daniel Lingwood
doaj   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Consensus-Guided Construction of H5N1-Specific and Universal Influenza a Multiepitope Vaccines

Biology
Background/Objectives: Influenza A viruses—including highly pathogenic H5N1—remain a global threat due to rapid evolution, zoonoses, and pandemic potential.
Marco Palma
doaj   +1 more source

Universal health plan proposal. Spanish

, 2022
Title from PDF caption (viewed on September 14, 2022)."El Grupo de Trabajo Conjunto sobre Atención Universal comenzó con la aprobación de la Ley 770 del Senado.

core  

The public health impact of malaria vaccine RTS,S in malaria endemic Africa: country-specific predictions using 18 month follow-up Phase III data and simulation models [PDF]

, 2015
The RTS,S/AS01 malaria vaccine candidate recently completed Phase III trials in 11 African sites. Recommendations for its deployment will partly depend on predictions of public health impact in endemic countries.
Katya Galactionova, Marcel Tanner, Michael Tarantino, Melissa A Penny, Smith, Thomas A., Galactionova, Katya, Tarantino, Michael, Thomas A Smith, Penny, Melissa A., Tanner, Marcel   +9 more
core   +1 more source

Programmable Carrier‐Free All‐Enzyme Beads for Modular Continuous‐Flow Biocatalysis

Advanced Materials, EarlyView.
Genetically encoded enzyme building blocks self‐assemble into monodisperse, carrier‐free protein beads via a droplet‐based formulation strategy. These programmable catalytic particles enable modular continuous‐flow biocatalysis, from single‐enzyme reactions to multi‐enzyme cascades and bead–bead coupled reactor systems.
Jennifer Kühne, Julian S. Hertel, André Delavault, Judith Felk, Martin Peng, Lara Reuber, Felix Ott, Kim Wanner, Marc F. Münker, Adrian Neukirch, Alexei Kiselev, Kersten S. Rabe, Christof M. Niemeyer   +12 more
wiley   +1 more source

Safety and immunogenicity of a seasonal trivalent inactivated split influenza vaccine: a phase I randomized clinical trial in healthy Serbian adults

Human Vaccines & Immunotherapeutics, 2018
This study was a phase I double-blind, randomized, placebo-controlled trial to evaluate the safety and immunogenicity of a Serbian-produced seasonal trivalent split, inactivated influenza vaccine in healthy adults. The vaccine was manufactured in eggs by
Goran Stevanovic, Lidija Lavadinovic, Svetlana Filipovic Vignjevic, Renée Holt, Katarina Ilic, Francesco Berlanda Scorza, Erin Sparrow, Vera Stoiljkovic, Guido Torelli, Tamra Madenwald, Muriel Socquet, Aleksandra Barac, Yordanka Ilieva-Borisova, Mijomir Pelemis, Jorge Flores   +14 more
doaj   +1 more source

Immune Responses Elicited by Live Attenuated Influenza Vaccines as Correlates of Universal Protection against Influenza Viruses

Vaccines, 2021
Influenza virus infection remains a major public health challenge, causing significant morbidity and mortality by annual epidemics and intermittent pandemics. Although current seasonal influenza vaccines provide efficient protection, antigenic changes of
Yo Han Jang, Baik L. Seong
doaj   +1 more source

Cost effectiveness of pediatric pneumococcal conjugate vaccines: a comparative assessment of decision-making tools. [PDF]

, 2011
BACKGROUND: Several decision support tools have been developed to aid policymaking regarding the adoption of pneumococcal conjugate vaccine (PCV) into national pediatric immunization programs.
A.M. Henao, Henao, Ana Maria, J. Hombach, Hutubessy, Raymond, Edmunds, John W, Beutels, Philippe, Joachim Hombach, Hutubessy Raymond, R. Somkrua, Chaiyakunapruk, Nathorn, Hombach, Joachim, R. Hutubessy, John W Edmunds, Ana Maria Henao, Philippe Beutels, Hombach Joachim, Nathorn Chaiyakunapruk, Henao Ana Maria, Edmunds John W, P. Beutels, Somkrua, Ratchadaporn, Edmunds, John W., Melegaro, Alessia, N. Chaiyakunapruk, Ratchadaporn Somkrua, Chaiyakunapruk Nathorn, Beutels Philippe, Raymond Hutubessy, Melegaro Alessia, Somkrua Ratchadaporn, Alessia Melegaro, W.J. Edmunds   +31 more
core   +2 more sources