Results 1 to 10 of about 108,558 (138)

Recombinant vector vaccine evolution.

PLoS Computational Biology, 2019
Replicating recombinant vector vaccines consist of a fully competent viral vector backbone engineered to express an antigen from a foreign transgene.
James J Bull, Scott L Nuismer, Rustom Antia   +2 more
doaj   +4 more sources

A novel malaria vaccine candidate antigen expressed in Tetrahymena thermophila [PDF]

, 2014
Development of effective malaria vaccines is hampered by the problem of producing correctly folded Plasmodium proteins for use as vaccine components.
A Huckriede, A Shevchenko, AF Egan, AF Egan, Alison M. Creasey, AP Turkewitz, AVS Hill, AW Stowers, B Sauer, BR Burgess, C Uthaipibull, CD Galamo, CF Ockenhouse, CG Adda, CHM Kocken, D Cassidy-Hanley, D Dodoo, D Gaur, D Hellenbroich, David R. Cavanagh, DB Smith, DC Gowda, DC Gowda, DE Arnot, DI Stanisic, DJ Conway, DK Moss, DP Mawili-Mboumba, DR Cavanagh, DR Cavanagh, DR Milich, DS Peterson, F Gharahdaghi, F Khan, G Jiang, GJM Cowan, Graeme J. M. Cowan, I Aldag, IA Quakyi, Ingo Aldag, J Gaertig, J Gaertig, JA Eisen, Janna Eleni-Muus, JC Pizarro, JJ Babon, JJ Gaertig, JS McBride, JS McBride, K Tanabe, Kay Samuel, LH Miller, M Parra, Marcus W. W. Hartmann, ME Victor, MJ Blackman, MJ Blackman, MJ Blackman, MJ Gardner, OS Lau, P Tompa, P Tompa, PA Burghaus, PD Crompton, Photini Sinnis, PR Sanders, PR Sanders, RR Garrity, SD Polley, T Kiy, T Weide, T Weide, UK Laemmli, Ulrike Bockau, V Chitarra, WA Keitel, WD Morgan, WD Morgan, Y Pollack, Y Shang   +79 more
core   +22 more sources

Fast antibody responses by immuno-targeting and nanotechnology strategies versus HBsAg vaccine [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Though immunization with HBsAg has been routine since the 1980s, it has numerous limitations such as low or none humoral immune responses. Today, nanotechnology is used in vaccinology to achieve higher potency.
Mahsa Rezaei, Seyed Nezamedin Hosseini, Ramazan Ali Khavari-Nejad, Farhood Najafi, Mehdi Mahdavi   +4 more
doaj   +1 more source

Development of an Adeno-Associated Virus-Vectored SARS-CoV-2 Vaccine and Its Immunogenicity in Mice

Frontiers in Cellular and Infection Microbiology, 2022
Owing to the outbreak of the novel coronavirus (SARS-CoV-2) worldwide at the end of 2019, the development of a SARS-CoV-2 vaccine became an urgent need.
Xi Qin, Shanhu Li, Xiang Li, Dening Pei, Yu Liu, Youxue Ding, Lan Liu, Hua Bi, Xinchang Shi, Ying Guo, Enyue Fang, Fang Huang, Lei Yu, Liuqiang Zhu, Yifang An, C. Alexander Valencia, Yuhua Li, Biao Dong, Yong Zhou   +18 more
doaj   +1 more source

Potentiation of the therapeutic effect of intravesical BCG through synthetic and biogenic selenium nanoparticles in a nitrosamine-induced bladder cancer mouse model

Advances in Cancer Biology - Metastasis, 2022
Introduction: Intravesical Mycobacterium Bovis bacillus Calmette-Guérin (BCG) therapy for non-muscle invasive bladder cancer has been successfully applied to prevent metastasis and disease progression.
Ramak Ajideh, Mohammad Reza Pourmand, Mohammad Ali Faramarzi, Zargham Sepehrizadeh, Gholamreza Pourmand, Seyed Mehdi Hassanzadeh, Mehdi Mahdavi, Ahmad Reza Shahverdi, Mohammad Hossein Yazdi   +8 more
doaj   +1 more source

Construction of a recombinant avipoxvirus expressing the env gene of Zika virus as a novel putative preventive vaccine

Virology Journal, 2021
Background Zika virus (ZIKV) has been declared a public health emergency that requires development of an effective vaccine, as it might represent an international threat. Methods Here, two novel DNA-based (pVAXzenv) and fowlpox-based (FPzenv) recombinant
Carlo Zanotto, Francesca Paolini, Antonia Radaelli, Carlo De Giuli Morghen   +3 more
doaj   +1 more source

Recombinant Influenza Vaccines [PDF]

Acta Naturae, 2012
This review covers the problems encountered in the construction and production of new recombinant influenza vaccines. New approaches to the development of influenza vaccines are investigated; they include reverse genetics methods, production of virus-like particles, and DNA- and viral vector-based vaccines.
Sedova, E., Shcherbinin, D., Migunov, A., Smirnov, Iu, Logunov, D., Shmarov, M., Tsybalova, L., Naroditskiĭ, B., Kiselev, O., Gintsburg, A.   +9 more
openaire   +3 more sources

Generation and evaluation of specific activity and authenticity of recombinant vaccine designed preventing against Pseudomonas aeruginosa

Инфекция и иммунитет, 2021
The aim of the study was to obtain and characterize a recombinant vaccine for the immunoprophylaxis of infections caused by Pseudomonas aeruginosa. A set of two highly immunogenic P. aeruginosa recombinant proteins was used to create related vaccine. The
A. A. Kaloshin, E. M. Zimina, E. O. Kalinichenko, N. A. Mihailova   +3 more
doaj   +1 more source

Safety and Immunogenicity of a Recombinant Tetanus Vaccine in Healthy Adults in China: A Randomized, Double‐Blind, Dose Escalation, Placebo‐ and Positive‐Controlled, Phase 1/2 Trial

Advanced Science, 2021
Tetanus is a fatal but vaccine‐preventable disease. The currently available tetanus vaccines are tetanus toxoid (TT)‐based. Although these vaccines are generally effective, challenges in vaccine development and access remain.
Xiaowei Xu, Rui Yu, Lanlan Xiao, Jie Wang, Meihong Yu, Junjie Xu, Yajun Tan, Xiao Ma, Xiaoxin Wu, Jiangshan Lian, Kaizhou Huang, Xiaoxi Ouyang, Sheng Bi, Shipo Wu, Xiaoyan Wang, Jiandi Jin, Ling Yu, Huafen Zhang, Qi Wei, Jinfa Shi, Wei Chen, Lanjuan Li   +21 more
doaj   +1 more source

Comparison of Immune Responses Elicited by SARS-CoV-2 mRNA and Recombinant Protein Vaccine Candidates

Frontiers in Immunology, 2022
After the outbreak of COVID-19, billions of vaccines with different types have been administrated, including recombinant protein vaccines and mRNA vaccines.
Yixin Wu, Huicong Zhang, Liuxian Meng, Fusheng Li, Fusheng Li, Changyuan Yu   +5 more
doaj   +1 more source