Results 81 to 90 of about 1,366,602 (255)

Recombinant RBD-based subunit vaccines incorporating high-frequency mutation sites elicit cross-immunity and robust protection against SARS-CoV-2

Frontiers in Microbiology
IntroductionSevere Acute Respiratory Syndrome Coronavirus type 2 (SARS-CoV-2), a highly pathogenic coronavirus (CoV) belonging to Coronavirus B, has triggered outbreaks or pandemics.
Zhiguang Ren, Zhiguang Ren, Xiawei Liu, Xiawei Liu, Weiyang Sun, Wei Jiang, Wei Jiang, Yiwen Li, Yiwen Li, Xiaonan Gao, Chengyu Hu, Menghan Zhu, Yongkun Zhao, Yuanguo Li, Xianzhu Xia, Zhengyan Yang, Jing Liu, Jing Liu, Xinrui Lv, Xinrui Lv, Tiecheng Wang, Tiecheng Wang, Daxiang Cui   +22 more
doaj   +1 more source

Demonstration of safety and enhanced seroprotection against hepatitis B with investigational HBsAg-1018 ISS vaccine compared to a licensed hepatitis B vaccine

, 2012
Adults 40 years of age and older have been shown to be hypo-responsive immunologically to the currently available hepatitis B virus (HBV) vaccines. Three intramuscular doses of a Toll-like receptor 9 agonist, 1018 immunostimulatory sequence (1018 ISS ...
안상훈
core  

Hepatitis B vaccination in the Columbian Amazon : effectiveness and factors influencing vaccine coverage [PDF]

A vaccination coverage survey was carried out in the Colombian Amazon, a former high endemic area for hepatitis B, involving 3573 children less than II years old. It was carried out in Leticia, Puerto Narifio, and Araracuara, both urban and rural areas.
De La Hoz, Fernando
core   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Site‐Specific Protein Bioconjugation Through Cellular Incorporation of Noncanonical Amino Acids

Angewandte Chemie, EarlyView.
Genetic code expansion (GCE) enables site‐specific installation of noncanonical amino acids containing bioorthogonal conjugation handles, allowing precise, homogeneous protein modification. This review examines the principles of orthogonal translation, surveys the chemistries available for chemoselective labeling, and highlights emerging multi‐site ...
Rahul Sarkar, Manas Joshi, Abhishek Chatterjee   +2 more
wiley   +2 more sources

Improved adjuvanting of seasonal influenza vaccines: Pre-clinical studies of MVA-NP+M1 co-administration with inactivated influenza vaccine. [PDF]

, 2013
Licensed seasonal influenza vaccines induce antibody responses against influenza hemagglutinin that are limited in their ability to protect against different strains of influenza.
Gilbert, SC, Temperton, Nigel J., Charleston, Bryan, Molesti, E, Sarah C. Gilbert, Butter, Colin, Massimiliano Baratelli, Lambe, Teresa, Boyd, A, Mullarkey, CE, Charleston, B, Caitlin E. Mullarkey, Eleonora Molesti, Gilbert, Sarah, van Laarhoven, Arjan, Veronica Carr, B, van Laarhoven, A, Eric A. Lefevre, Molesti, Eleonora, Amy Boyd, Colin Butter, Mullarkey, Caitlin E, Gilbert, Sarah C, Lefevre, EA, B. Veronica Carr, Arjan van Laarhoven, Nigel J. Temperton, Lambe, T, Baratelli, M, Carr, B Veronica, Baratelli, Massimiliano, Lefevre, Eric A, Boyd, Amy, Temperton, NJ, Butter, C, Teresa Lambe, Bryan Charleston   +36 more
core   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Role of universal and targeted recommendations for vaccines for sexually transmitted infections in the USA, China and Indonesia: a cross-sectional study

BMJ Public Health
Background Vaccines for sexually transmitted infections (STIs) are in development and little is known about their future acceptance. The type of recommendations released by National Immunisation Technical Advisory Groups could influence vaccine uptake ...
Abram L Wagner, Maria Alexandra Santana-Garces, Harapan Harapan, Yihan Lu   +3 more
doaj   +1 more source

Influenza vaccination and the ‘diversity paradox’

Human Vaccines & Immunotherapeutics, 2018
The antigenic evolution of influenza is widely assumed to occur by antigenic drift, in which strains incrementally acquire mutations in highly variable epitopes under strong immune selective pressure, such as those in the major influenza antigen ...
Craig P. Thompson, Uri Obolski
doaj   +1 more source

Optimization of microcarrier cell culture process for the inactivated enterovirus type 71 vaccine development

, 2008
[[abstract]]Enterovirus 71 (EV71) is an enterovirus that could lead to severe neurological disorders and fatalities. The inactivated vaccine is an appropriate EV71 vaccine format for meeting current needs.
Wu, SC; Liu, CC; Lian, WC
core   +1 more source