Results 101 to 110 of about 15,075 (306)

The policy of cosmopolitism: from universalism to pluralism [PDF]

open access: yesКантовский сборник, 2013
This article is devoted to the search for an adequate justification for the modern policy of cosmopolitism. The author maintains that the legitimation of cosmopolitism is of rather cultural than political nature.
Castillio M.
doaj  

The expanding universe [PDF]

open access: yesProceedings of the Physical Society, 1932
I THINK everyone will agree with Miss Clark that if the distribution of nebular velocities is considered to be mainly a distance effect, it indicates an expanding system, whereas if it is mainly a time effect it indicates a system which is about to enter on a stage of contraction; and her letter is of service in pointing out the two alternatives ...
openaire   +4 more sources

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina   +11 more
wiley   +1 more source

Posterior Cortical Atrophy in the Asia‐Pacific: A Report From the PCA Asian Workgroup

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Posterior Cortical Atrophy (PCA) is a distinct dementia syndrome primarily affecting spatial abilities and visual processing. It is associated with degeneration in the posterior part of the brain. PCA is subclassified into PCA‐pure and PCA‐plus syndromes based on consensus criteria.
Yuttachai Likitjaroen   +11 more
wiley   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

The policy of cosmopolitism: from universalism to pluralism (translated from French by D. Ye. Fetisova) [PDF]

open access: yesКантовский сборник, 2013
This article is devoted to the search for an adequate justification for the modern policy of cosmopolitism. The author maintains that the legitimation of cosmopolitism is of rather cultural than political nature.
Castillio M.
doaj  

Mediating Welfare Ethics:Selectivity Or Universalism?

open access: yes, 2003
This paper explores some of the underpinning ideologies that drive Australia’s selective income support system, by examining the ethical justifications used to support targeted welfare systems such as Mutual Obligation.
Schooneveldt, Simon P.
core  

LEGAL UNIVERSALISM: PERSISTENT OBJECTIONS

open access: yes, 2010
This essay addresses the question of whether there is any set of legal institutions that invariably promotes development. ‘Universalistic’ arguments answer this question in the affirmative.
Kevin E. Davis
core   +1 more source

Sex Representation in US Stroke Clinical Trials: A Decade of Trends and Challenges

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stroke remains a major cause of disability and mortality in the US, with significant sex‐based disparities, and females remain underrepresented in stroke clinical trials. We aimed to examine sex representation in US‐based stroke clinical trials, identify trial characteristics associated with higher female enrollment (≥ 50%), and ...
Chaitali Dagli   +5 more
wiley   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan   +9 more
wiley   +1 more source

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