Results 91 to 100 of about 15,085 (306)
Molecular Oncology, EarlyView.Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi +14 more
wiley +1 more source
Does universalism entail extensionalism? [PDF]
, 2016 Does a commitment to mereological universalism automatically bring along a commitment to the controversial doctrine of mereological extensionalism—the view that objects with the same proper parts are identical?
Cotnoir, Aaron
core +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
"Universalism, Pluralism or Isolationism? The Relationship between Authors' Rights & Creators' Human Rights" [PDF]
, 2019 It is sometimes suggested that authors’ rights are protected under international human rights law. This claim is often supported by reference to the “creators’ rights” established under Article 27(2) of the Universal Declaration of Human Rights (UDHR ...
Griffiths, J
core
John Rawls’ interpretation of categorical imperative in “Theory of Justice” [PDF]
Кантовский сборник, 2013 John Rawls’s interpretation of Kant’s categorical imperative is reviewed, some significant aspects of Rawls’ treatment of key notions of rationality, interests and ends are revealed, which limit the possibilities of application of Kantian ethics within ...
Chaly V. A.
doaj
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
'Is universalism a problem for particularists?' [PDF]
, 2010 In a previous article entitled ‘Augustinian Universalism’, I argued that the principles of Augustinianism are compatible with universalism. For those who reason to Augustinianism on the basis of biblical-theological arguments, this may not be terribly ...
Crisp, OD
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Universalism and Particularism [PDF]
, 2017 This chapter argues that current strands of the theories on international, supranational, and transnational law are on the road to leaving the dichotomy of universalism and particularism.
Armin von Bogdandy, Sergio Dellavalle
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The Value of the Persistent Objector Doctrine in International Human Rights Law
Potchefstroom Electronic Law Journal, 2019 This article critically analyses the use of the persistent objector doctrine in unilaterally challenging the validity of Sexual Orientation and Gender Identity (SOGI) rights and the related state obligations. The persistent objector doctrine gives effect
Annika Rudman
doaj +1 more source