Results 71 to 80 of about 15,075 (306)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Idea of the Integrity of Social Being in Russian Religious Philosophy

Управленческое консультирование
The article considers the understanding of the nature of public life as some integrity in Russian religious philosophy. It is shown that the main specificity of the way of thinking of Russian philosophers is to distinguish between the empirical reality ...
V. B. Aleksandrov
doaj   +1 more source

Marx\u27s Political Universalism

, 1996
My main aim in this paper is to arrive at a defensible form of Marxian or socialist political universalism through a critical examination of Marx\u27s own political universalism.
van der Linden, Harry
core   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Making Universal Policies Universal

International Joint Conference on Autonomous Agents and Multiagent Systems
The development of a generalist agent capable of solving a wide range of sequential decision-making tasks remains a significant challenge. We address this problem in a cross-agent setup where agents share the same observation space but differ in their action spaces.
Hoepner, Niklas, Kuric, David, van Hoof, Herke   +2 more
openaire   +3 more sources

University Extension and the State University [PDF]

Science, 1911
n ...
openaire   +3 more sources

Learning at the University - conceptions of university teachers

, 2020
Academia, No 22 (2021)
Chaleta, Elisa, Saraiva, Margarida
openaire   +4 more sources

The old question of Barth’s universalism: an examination with reference to Tom Greggs and T. F. Torrance

, 2013
In the course of reflecting on Tom Greggs' recent claim that Barth ‘did not reject universalism [...] only problematic elements associated with it’, Mark Koonz raises the fascinating question of Barth’s doctrinal position on universalism.
Koonz, Mark
core