Results 81 to 90 of about 15,085 (306)

Déplacements, décentrages : le roman en transit

open access: yesBrésil(s), 2015
This article proposes the notions of displacement and decentering, in order to explore the possibilities presented by understanding the novel as a transnational genre, that is, a genre which, despite being rooted in specific contexts, has traversed or ...
Sandra Guardini Teixeira Vasconcelos
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Mediating Welfare Ethics:Selectivity Or Universalism? [PDF]

open access: yes, 2003
This paper explores some of the underpinning ideologies that drive Australia’s selective income support system, by examining the ethical justifications used to support targeted welfare systems such as Mutual Obligation.
Schooneveldt, Simon P.
core  

LEGAL UNIVERSALISM: PERSISTENT OBJECTIONS [PDF]

open access: yes, 2010
This essay addresses the question of whether there is any set of legal institutions that invariably promotes development. ‘Universalistic’ arguments answer this question in the affirmative.
Kevin E. Davis
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

The Universalism of Human Rights / [PDF]

open access: yes, 2019
Is there universalism of human rights? If so, what are its scope and limits? This book is a doctrinal attempt to define universalism of human rights, as well as its scope and limits.
Arnold, Rainer,
core   +1 more source

The Idea of the Integrity of Social Being in Russian Religious Philosophy

open access: yesУправленческое консультирование
The article considers the understanding of the nature of public life as some integrity in Russian religious philosophy. It is shown that the main specificity of the way of thinking of Russian philosophers is to distinguish between the empirical reality ...
V. B. Aleksandrov
doaj   +1 more source

Making Universal Policies Universal

open access: yesInternational Joint Conference on Autonomous Agents and Multiagent Systems
The development of a generalist agent capable of solving a wide range of sequential decision-making tasks remains a significant challenge. We address this problem in a cross-agent setup where agents share the same observation space but differ in their action spaces.
Hoepner, Niklas   +2 more
openaire   +3 more sources

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