Results 81 to 90 of about 15,075 (306)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
John Rawls’ interpretation of categorical imperative in “Theory of Justice” [PDF]
Кантовский сборник, 2013 John Rawls’s interpretation of Kant’s categorical imperative is reviewed, some significant aspects of Rawls’ treatment of key notions of rationality, interests and ends are revealed, which limit the possibilities of application of Kantian ethics within ...
Chaly V. A.
doaj
"Universalism, Pluralism or Isolationism? The Relationship between Authors' Rights & Creators' Human Rights" [PDF]
, 2019 It is sometimes suggested that authors’ rights are protected under international human rights law. This claim is often supported by reference to the “creators’ rights” established under Article 27(2) of the Universal Declaration of Human Rights (UDHR ...
Griffiths, J
core
Moral Universalism: Global Evidence
, 2022 This paper presents novel stylized facts about the global variation in universalism, leveraging nationally representative surveys across 60 countries (N=64,000).
Enke, Benjamin +2 more
core
Acute caffeine treatment protects the developing retina from ischemia‐induced cell death
FEBS Open Bio, EarlyView.Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento +6 more
wiley +1 more source
, 2020 This chapter explores the ways in which the Canadian Broadcasting Corporation (CBC) has embraced the idea of universal service. While the CBC was not legislatively mandated to elements of universality until 1968, throughout its history, Canada’s public ...
Skinner, David
core +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
The Value of the Persistent Objector Doctrine in International Human Rights Law
Potchefstroom Electronic Law Journal, 2019 This article critically analyses the use of the persistent objector doctrine in unilaterally challenging the validity of Sexual Orientation and Gender Identity (SOGI) rights and the related state obligations. The persistent objector doctrine gives effect
Annika Rudman
doaj +1 more source
FEBS Open Bio, EarlyView.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
Precedentes vinculantes à brasileira?
Teoria Jurídica Contemporânea, 2017 RESUMO: Trata-se de breve estudo sobre as regras processuais que atribuem certos graus de efeito vinculante a determinados pronunciamentos judiciais, tais como encartadas pelo legislador de 2015 no subsistema instituído pelo Novo Código de Processo ...
Murilo Strätz
doaj +1 more source