Results 41 to 50 of about 193,011 (317)

Kant’s normative moral theory: Apparent moral universalism and the challenge of persistent structural racism

open access: yesRivista di Estetica
Kant is famous for his doctrine of moral universalism. But in his writings on anthropology, physical geography, and history, he distinguished between four different human races, claiming that only members of the white, European race had developed the ...
Christel Fricke
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Normative structure of science and sociological ambivalence [PDF]

open access: yesSociološki Pregled, 2008
This paper is about one of the most influential ideas in sociology of science - Robert Merton's normative structure of science. The problem of sociological ambivalence is closely related with it.
Škorić Marko
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Remembering a sociology of Human Rights

open access: yesCulture & History Digital Journal, 2014
A sociology of human rights sounds almost like a contradiction in terms. Sociology is about social groups, about particular experiences, about how people, embedded in space and time, make sense of their lives and give meaning to their world.
Daniel Levy, Natan Sznaider
doaj   +1 more source

Reconstructing the Universe [PDF]

open access: yesPhysical Review D, 2005
52 pages, 20 postscript figures, added ...
Ambjørn, Jan   +2 more
openaire   +6 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Universalism and Queer Entanglements

open access: yesMiranda: Revue Pluridisciplinaire du Monde Anglophone
Given the rapid homogenisation of queer discourse transnationally through its attachment to Euro-US avatars, it has become commonplace to consider the normativity of the queer-as-antinormative narrative as a “field-defining rule” (Wiegman and Wilson ...
Sandeep Bakshi
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Concurrences in Contemporary Travel Writing: Postcolonial Critique and Colonial Sentiments in Sven Lindqvist's Exterminate all the Brutes and Terra Nullius

open access: yesCulture Unbound: Journal of Current Cultural Research, 2014
Recent research highlights contemporary travel writing's complicity in global politics, and the genre is claimed to reproduce the discourses that constitute our understanding of the world.
Piia K. Posti
doaj   +1 more source

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