Results 51 to 60 of about 1,149,515 (356)

Values Following a Major Terrorist Incident: Finnish Adolescent and Student Values Before and After September 11, 2001 [PDF]

, 2006
The horrific terrorist attacks on the United States on September 11, 2001, left an indelible mark on perceptions of security and threat across the world.
Applewhite, Boehnke, Bogt, Bowles, Cavalli-Sforza, Goodwin, Hofstede, Inglehart, Janoff-Bulman, Kohn, Ladd, Maslow, Morgan, Myyry, Norris, Raviv, Raviv, Rohan, Rokeach, Sagiv, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schwartz, Schönpflug, Schönpflug, Skarzynska, Sprang, Tartakovsky, Verkasalo, Verkasalo, Vertzberger, Vos   +35 more
core   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Fatal attraction: a critique of Carl Schmitt's international political and legal theory [PDF]

, 2011
The ongoing Schmitt revival has extended Carl Schmitt's reach over the fields of international legal and political theory. Neo-Schmittians suggest that his international thought provides a new reading of the history of international law and order, which ...
Agamben, Anderson, Anderson, Balakrishnan, Bendersky, Benno Gerhard Teschke, Bonney, Brenner, Brewer, Brewer, Brown, Cocker, Colas, De Benoist, Diner, Diner, Downing, Fisch, Gowan, Habermas, Habermas, Haggenmacher, Hardt, Holmes, Joerges, Kelsen, Kervégan, Kunisch, Körner, Lilla, Marx, Mehring, Miller, Mouffe, Mouffe, Mouffe, Müller, O'Brien, Odysseos, Odysseos, Odysseos, Ojakangas, Opitz, Parker, Petito, Rasch, Repgen, Rüthers, Rüthers, Scheuerman, Scheuerman, Scheuerman, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmitt, Schmoeckel, Schroeder, Shapiro, Smith, Stirk, Stirk, Teschke, Tilly, Tooze, Wehler, Wolf, Wood, Wood, Wright, Zolo, Zolo, Žižek   +78 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The Illusion of Purity:Chantal Mouffe's Realist Critique of Cosmopolitanism [PDF]

, 2010
Over the last 20 years, cosmopolitan theories have been benefiting greatly from the dialogue between defenders and critics of world citizenship.
Thaler, Mathias
core   +1 more source

Does Spontaneous Favorability to Power (vs. Universalism) Values Predict Spontaneous Prejudice and Discrimination?

Journal of Personality, 2016
Objective We conducted five studies testing whether an implicit measure of favorability toward power over universalism values predicts spontaneous prejudice and discrimination.
N. Souchon, G. Maio, P. Hanel, B. Bardin
semanticscholar   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Modified universalism as customary international law

, 2018
“Modified universalism” is to date the dominant approach for addressing cross-border insolvency. Heavily influenced by the scholarship and advocacy of Professor Jay Westbrook, it has evolved into a set of norms that can guide parties in actual cases ...
Irit Mevorach
semanticscholar   +1 more source