Results 91 to 100 of about 1,105,380 (358)

Universality of Human Microbial Dynamics

open access: yesNature, 2016
A new computational method to characterize the dynamics of human-associated microbial communities is applied to data from two large-scale metagenomic studies, and suggests that gut and mouth microbiomes of healthy individuals are subjected to universal ...
A. Bashan   +6 more
semanticscholar   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

ARE HUMAN RIGHTS OF RELIGIOUS ORIGIN?

open access: yesSur: International Journal on Human Rights, 2019
Are human rights codified in the late eighteenth century by natural rights of divine or philosophical origin? This question haunted Western political thought throughout the nineteenth and twentieth centuries.
Valentine Zuber
doaj  

How “Universal” are Universal Precautions?

open access: yesAMA Journal of Ethics, 2009
Guidelines to improve observance of universal precaution standards and reporting of needlestick injuries by medical students and resident physicians. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire   +2 more sources

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Actin dynamics controlled by IqgC, a RasGAP at the crossroads between the IQGAP and fungal GAP1 families

open access: yesFEBS Open Bio, EarlyView.
IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić   +3 more
wiley   +1 more source

On Universality of Some Beurling Zeta-Functions

open access: yesAxioms
Let P be the set of generalized prime numbers, and ζP(s), s=σ+it, denote the Beurling zeta-function associated with P. In the paper, we consider the approximation of analytic functions by using shifts ζP(s+iτ), τ∈R. We assume the classical axioms for the
Andrius Geštautas, Antanas Laurinčikas
doaj   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

open access: yesFEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee   +3 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

When Hell is Other People. Interiority and Skepticism in António Lopes da Veiga

open access: yesCulture & History Digital Journal, 2017
The study of the process of construction of modern subjectivity offers an image of constant tensions between universality and particularity, which could be considered a manifestation of the conflictual nature of Modernity itself.
Fernando Rodríguez Mediano   +1 more
doaj   +1 more source

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