Results 91 to 100 of about 1,193,242 (318)

První koncepce kulovité Země v antické kosmologii

open access: yesFilosofický časopis, 2022
Although it is not until we get to Aristotle that we can be absolutely certain of finding a spherical Earth in ancient cosmology, Diogenes Laertios considers it to have been first conceived by Pythagoras and Parmenides.
Kočandrle, Radim
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

open access: yesFEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan   +2 more
wiley   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

open access: yesFEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile   +8 more
wiley   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

open access: yesFEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

No-Boundary Wave Functional and Own Mass of the Universe

open access: yesUniverse
An alternative formulation of the no-boundary initial state of the universe in the Euclidean quantum theory of gravity is proposed. Unlike the no-boundary Hartle–Hawking wave function, in which time appears together with macroscopic space–time in the ...
Natalia Gorobey   +2 more
doaj   +1 more source

How to create a universe [PDF]

open access: yes, 2007
The purpose of this paper is (i) to expound the specification of a universe, according to those parts of mathematical physics which have been experimentally and observationally verified in our own universe; and (ii) to expound the possible means of ...
McCabe, Gordon
core   +2 more sources

Universality

open access: yes, 2015
This article deals with the universality of eigenvalue spacings, one of the basic characteristics of random matrices. It first discusses the heuristic meaning of universality before describing the standard universality classes (sine, Airy, Bessel) and their appearance in unitary, orthogonal, and symplectic ensembles.
openaire   +2 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

Man and Universe

open access: yesТеорія і практика правознавства, 2019
The knowledge of the Universe is an integral part of understanding of human nature. People can perceive themselves, their nature, essence, relations with other people only through learning and understanding the world, the laws of evolution and existence.
Valentina Petrovna Simonok
doaj   +1 more source

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