Results 71 to 80 of about 113,830 (296)

Science and Ideology: The Case of Cosmology in the Soviet Union, 1947–1963

open access: yesActa Baltica Historiae et Philosophiae Scientiarum, 2013
Ideological considerations have always influenced science, butrarely as directly and massively as in the Soviet Union during the early Cold War period, when cosmology was among the sciences that became politicized.
Kragh, Helge
doaj   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

open access: yesFEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke   +2 more
wiley   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

open access: yesFEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner   +7 more
wiley   +1 more source

The Problem of Unity and Plurality in Teftâzânî

open access: yesDin ve Bilim Muş Alparslan Üniversitesi İslami İlimler Fakültesi Dergisi
In the religious texts of Muslims, some commands praise all forms of wisdom and emphasize the necessity of acquiring wisdom wherever it is found. For this reason, from the early periods, the Islamic intellectual movement made great efforts to become ...
Ekrem UĞURLU
doaj   +1 more source

The Adventures of Road Workers (1974–1980): National Specificity of the Georgian Trio [PDF]

open access: yesХудожественная культура
The author focuses on a series of short films about road workers, created in 1974–1980 by different directors of the Georgia Film studio based on the scripts by Rezo Gabriadze.
Evallyo Violetta D.
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

open access: yesFEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

İnsanın Yabancılaşmasına Yönelik Sȗfȋ Perspektif / Sufi Perspective of Human Alienation / اغتراب الإنسان من خلال المنظور الصوفي

open access: yesİlahiyat Akademi, 2016
En büyük kriz insanlık krizidir. Ekonomik, sosyal, siyasal ve kültürel krizler belki bir şekilde aşılabilir ama insanlık krizi tamiri kolay olmayan büyük yaralar açar. O nedenle en büyük yatırım insana yapılan yatırımdır.
Kadir Özköse
doaj  

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

open access: yesFEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg   +2 more
wiley   +1 more source

Universality

open access: yes, 2015
This article deals with the universality of eigenvalue spacings, one of the basic characteristics of random matrices. It first discusses the heuristic meaning of universality before describing the standard universality classes (sine, Airy, Bessel) and their appearance in unitary, orthogonal, and symplectic ensembles.
openaire   +2 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

open access: yesFEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro   +2 more
wiley   +1 more source

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