Results 111 to 120 of about 6,075,495 (359)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Selection of Raw Material Suppliers Using Analytical Hierarchy Process in Food and Beverage Company, South Jakarta

open access: yesComTech, 2017
The purpose of this research was to see the selection of raw material suppliers as an assessment of supplier performance. Data were obtained from the results of assessment of the experts in food and beverage company in South Jakarta.
Jakfat Haekal, Herawan Setio
doaj   +1 more source

How “Universal” are Universal Precautions?

open access: yesAMA Journal of Ethics, 2009
Guidelines to improve observance of universal precaution standards and reporting of needlestick injuries by medical students and resident physicians. Virtual Mentor is a monthly bioethics journal published by the American Medical Association.
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Climbing the Ladder: An Authentic Leadership Program Boosting Adolescent Girls’ Potential.

open access: yesSAGE Open
This study explores the realm of authentic leadership theory to examine how female teenagers can enhance relational authenticity and develop authentic leadership skills through a specialized program. Employing multigroup Structural Equation Modeling (SEM)
Manuel M. Molina-López   +3 more
doaj   +1 more source

The expanding universe [PDF]

open access: yesProceedings of the Physical Society, 1932
I THINK everyone will agree with Miss Clark that if the distribution of nebular velocities is considered to be mainly a distance effect, it indicates an expanding system, whereas if it is mainly a time effect it indicates a system which is about to enter on a stage of contraction; and her letter is of service in pointing out the two alternatives ...
openaire   +4 more sources

Diffusion of sustainability reporting in universities: current situation and future perspectives

open access: yes, 2015
Universities play a key role in the development of society, and their involvement in sustainable development will be crucial in changing current practices in society towards sustainable development.
M. Alonso‐Almeida   +3 more
semanticscholar   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy