Results 51 to 60 of about 56,617 (254)

FKBP5/FKBP51-mediated signaling pathways in neuropsychiatric diseases: Insights for biomarker development and targeted therapies

Neurobiology of Stress
The FK506-binding protein 5 gene encodes FKBP51, a molecular chaperone linked to the pathogenesis of neuropsychiatric diseases. Recent evidence shows that FKBP51 modulates activity of the HPA axis and GR-mediated feedback via dynamic interactions with GR,
Yinglong Liu, Jiahe Lian, Youli Fu, Shishan Wang, Yongxin Liu, Rui Zhang, Huirong Han   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Convolutional Neural Networks-Based Object Detection Algorithm by Jointing Semantic Segmentation for Images

Sensors, 2020
In recent years, increasing image data comes from various sensors, and object detection plays a vital role in image understanding. For object detection in complex scenes, more detailed information in the image should be obtained to improve the accuracy ...
Baohua Qiang, Ruidong Chen, Mingliang Zhou, Yuanchao Pang, Yijie Zhai, Minghao Yang   +5 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

FDPNet: Frequency Guided Prior Decoupling Network for Remote Sensing Change Detection

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Remote sensing change detection aims to precisely identify the areas where the types or states of ground objects change over time. However, remote sensing images are often disturbed by factors such as seasons or changes in lighting in practical ...
Kaisheng Li, Zhaolong Gao, Haiyan Du
doaj   +1 more source

Partnership Approach to Establishing Tobacco-Free Colleges and Universities in Georgia

Journal of the Georgia Public Health Association, 2016
Background: Smoking rates in young adults ages 18-24 have been steadily declining since 2011 (2011:25.0%, 2012:22.3%, 2013:16.5% (BRFSS). The Georgia Department of Public Health (GDPH) partnered with the Georgia Board of Regents to adopt the 100% Tobacco
Anne-Marie Coleman, Kenneth Ray, Kia Toodle, Alina Chung, Jean O'Connor   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Fasciola gigantica Recombinant Abelson Tyrosine Protein Kinase (rFgAbl) Regulates Various Functions of Buffalo Peripheral Blood Mononuclear Cells

Animals
Fasciola gigantica can modulate host immune mechanisms through excretory–secretory products (ESP). As one of the components of ESP, it is unknown whether Abelson tyrosine protein kinase (Abl) is involved in parasite–host immune interaction.
Min Zhao, Yu Zou, Wanting Chen, Dongqi Wu, Chengjun Xian, Haoqing Yang, Jiacheng Tan, Wenda Di, Wende Wu, Dongying Wang   +9 more
doaj   +1 more source

The state of coursework on horses in human services at universities and colleges in the United States: a scoping review. [PDF]

Front Vet Sci, 2023
Connolly K, Ekholm Fry N.
europepmc   +1 more source