Results 71 to 80 of about 104,996 (303)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Association of American Colleges and Universities

open access: yes, 2005
Titre de la page Web (visionnée le 23 déc ...
Association of American Colleges and Universities
core  

Applicability of mitotic figure counting by deep learning: a development and pan‐cancer validation study

open access: yesFEBS Open Bio, EarlyView.
In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes   +32 more
wiley   +1 more source

20th anniversary: history of UCEA

open access: yes, 2014
Retrospective account of the development of collective bargaining, trade unions and employers' associations in the UK Higher Education sector.
Universities and Colleges Employers Association   +1 more
core  

What role for public policy in promoting philanthropy? The case of EU universities [PDF]

open access: yes, 2011
This article presents and discusses the findings of a survey conducted among Higher Educational Institutions (HEIs) in most of the twenty-seven countries within the European Union, which studied the extent and success of fundraising from philanthropic ...
Gouwenberg, Barbara   +11 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Physiology and Transcriptome Analysis of Exogenous GA3 Effects on the Seed Germination of Phyllostachys edulis

open access: yesCurrent Issues in Molecular Biology
Phyllostachys edulis is a vital bamboo resource in China, known for its economic benefits and ecological functions. However, under natural conditions, its seed germination rate is very low.
He Liao   +4 more
doaj   +1 more source

A parallel algorithm for network traffic anomaly detection based on Isolation Forest

open access: yesInternational Journal of Distributed Sensor Networks, 2018
With the rapid development of large-scale complex networks and proliferation of various social network applications, the amount of network traffic data generated is increasing tremendously, and efficient anomaly detection on those massive network traffic
Xiaoling Tao   +4 more
doaj   +1 more source

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