Results 81 to 90 of about 56,617 (254)

Pollen and Floral Organ Morphology of 18 Oil-Tea Genotypes and Its Systematic Significance

Horticulturae
Oil-tea belongs to the Camellia genus, an important oil crop in China. However, oil-tea is taxonomically challenging due to its morphological variation, polyploidy, and interspecific hybridization.
Qian Yin, Zhongfei Pan, Yanming Li, Huan Xiong, Joseph Masabni, Deyi Yuan, Feng Zou   +6 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Scientific Methods and Sacred Matters: On Methodological Naturalism, Divine Agency, and Christians in Science

Zygon
This article critically analyzes the debate surrounding methodological naturalism (MN) within the context of scientific inquiry, focusing on the arguments put forth by Andrew Torrance on the one hand and John Perry and Sarah Lane Ritchie on the other. It
Mitchell Mallary
doaj   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A segmentation-combination data augmentation strategy and dual attention mechanism for accurate Chinese herbal medicine microscopic identification

Frontiers in Plant Science
IntroductionChinese Herbal Medicine (CHM), with its deep-rooted history and increasing global recognition, encounters significant challenges in automation for microscopic identification.
Xiaoying Zhu, Xiaoying Zhu, Guangyao Pang, Guangyao Pang, Xi He, Xi He, Yue Chen, Yue Chen, Zhenming Yu   +8 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

The complete chloroplast genomes of four Aspidopterys species and a comparison with other Malpighiaceae species

Scientific Reports
The genus Aspidopterys has multiple functions in medicine, food and ecological restoration. Due to the similar morphological characteristics of some species and the limited genomic information hinder the studies on germplasm identification and molecular ...
He Liao, Huayuan Chen, Shinan Liu
doaj   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Phylotaxonomic analysis uncovers underestimated species diversity within the genus Rossellomorea with description of selenium-resistant Rossellomorea yichunensis sp. nov

BMC Microbiology
A novel Gram-stain-positive, aerobic, motile, rod-shaped strain, designated as YC4-1 T, was isolated from rhizosphere soil of Ageratum conyzoides collected from a selenium-rich area in Yichun, Jiangxi Province, China.
Jiejie Kong, Ziyue Fu, Qianyang Zhang, Yiqin Liu, Zixuan Luo, Zhigang Zhao, Liangliang Liu, Xiaolong Liu, Dan Xu, Xingjie Li, Daofeng Zhang   +10 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source