Results 71 to 80 of about 399,066 (305)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

State and Local Environmental Information Centers, Facilities, and Services [PDF]

, 1972
The federal Environmental Protection Agency has already kindly provided the first edition of a catalog of state and local environmental libraries. 1 However, I wish to provide more than such a catalog.
Imberman, Angela
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

“Dystrophia Myotonica” and the legacy of hans gustav wilhelm steinert

Annals of Indian Academy of Neurology, 2018
The objective of this analysis is to study the life of Hans Gustav Wilhelm Steinert and his role in identifying several neurologic disorders including myotonic dystrophy (DM). DM type 1 (DM1) is a commonly inherited adult muscle disorder.
Shri Kant Mishra, Sandeep Singh, Brian Lee, Shaweta Khosa, Negar Moheb, Vishal A Tandon   +5 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Data Visualization: A Guide to Visual Storytelling for Libraries

Journal of the Medical Library Association, 2018
A compilation of twelve chapters, Data Visualization: A Guide for Visual Storytelling for Libraries provides an introduction for librarians on how they can effectively communicate through visualizing how their collections and services are being used.
Nathalie Reid
doaj   +1 more source

Digital learning objects: a local response to the California State University system initiative [PDF]

, 2009
The purpose of this paper is to present a virtual library plan created by library directors of the 23 California State University (CSU) system campuses.
Davis, Jennifer, Howard, Francis E, Hunsaker, Marci, Liu, Shu-Hua   +3 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Review, Revise, and (re)Release: Updating an Information Literacy Tutorial to Embed a Science Information Life Cycle.

Issues in Science and Technology Librarianship, 2013
In 2008, University of California, Irvine (UCI) Libraries launched their first Find Science Information online tutorial. It was an innovative web-based tool, containing not only informative content but also interactive activities, embedded hyperlinked ...
Jeffra Diane Bussmann, Caitlin E. Plovnick   +1 more
doaj   +1 more source

The Place of Rare Books in a College or University Library [PDF]

, 1940
published or submitted for ...
Adams, Randolph G.
core   +1 more source