Results 91 to 100 of about 6,759,956 (334)

Denosumab Safety and Efficacy Among Participants in the FREEDOM Extension Study With Mild to Moderate Chronic Kidney Disease

Journal of Clinical Endocrinology and Metabolism, 2020
Context The effects of long-term exposure to denosumab in individuals with renal insufficiency are unknown. Objective This post hoc analysis evaluates the long-term safety and efficacy of denosumab in individuals with mild-to-moderate chronic kidney ...
A. Broadwell, A. Chines, P. Ebeling, E. Franek, Shuang Huang, Shawna N Smith, D. Kendler, O. Messina, P. Miller   +8 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Long-term longitudinal analysis of 4,187 participants reveals insights into determinants of clonal hematopoiesis

Nature Communications
Clonal hematopoiesis of indeterminate potential (CHIP) is linked to diverse aging-related diseases, including hematologic malignancy and atherosclerotic cardiovascular disease (ASCVD).
M. Uddin, S. Saadatagah, A. Niroula, Bing Yu, Whitney E. Hornsby, Shri K Ganesh, Kim Lannery, A. Schuermans, M. Honigberg, A. Bick, Peter Libby, Benjamin L. Ebert, C. Ballantyne, P. Natarajan   +13 more
semanticscholar   +1 more source

Neurological Autoantibody Prevalence in Epilepsy of Unknown Etiology

JAMA Neurology, 2017
Importance Autoimmune epilepsy is an underrecognized condition, and its true incidence is unknown. Identifying patients with an underlying autoimmune origin is critical because these patients’ condition may remain refractory to conventional antiseizure ...
D. Dubey, Abdulradha Alqallaf, Ryan Hays, M. Freeman, Kevin Chen, Kan Ding, M. Agostini, S. Vernino   +7 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Estimating Unknown English Words From User Smartphone Reading Behaviors

IEEE Access
Vocabulary learning is essential for language study, and it is crucial to identify unknown words for users. Conventional English vocabulary learning methods specify words to be learned based on the frequency of vocabulary use and cannot suggest unknown ...
Riku Higashimura, Ko Watanabe, Andrew Vargo, Motoi Iwata, Andreas Dengel, Koichi Kise   +5 more
doaj   +1 more source

The effect of Parkinson’s disease subgroups on verbal and nonverbal fluency [PDF]

, 2014
BACKGROUND: Parkinson’s disease (PD) leads to deficits in executive function, including verbal and nonverbal fluency, as a result of compromised frontostriatal circuits.
Cronin-Golomb, Alice, Jaywant, Abhishek, Musto, Giovanni, Neargarder, Sandy, Stavitsky Gilbert, Karina   +4 more
core   +1 more source

Research is ‘a step into the unknown’: an exploration of pharmacists’ perceptions of factors impacting on research participation in the NHS [PDF]

BMJ Open, 2015
ObjectiveThis study explored National Health Service (NHS) pharmacists’ perceptions and experiences of pharmacist-led research in the workplace.DesignSemistructured, face-to-face discussions continued until distinct clusters of opinion characteristics formed.
Lowrie, Richard, Morrison, Graeme, Lees, Rosalind, Grant, Christopher H., Johnson, Chris, MacLean, Fiona, Semple, Yvonne, Thomson, Alison, Harrison, Heather, Mullen, Alexander B, Lannigan, Norman, Macdonald, Sara   +11 more
openaire   +5 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Does Foreign-Accented Speech Affect Credibility? Evidence from the Illusory-Truth Paradigm

Journal of Cognition
In a pioneering study, Lev-Ari and Keysar (2010) observed that unknown statements are judged less credible when uttered with foreign accent compared to native accent.
Anna Lorenzoni, Rita Faccio, Eduardo Navarrete   +2 more
doaj   +1 more source