Results 111 to 120 of about 6,759,956 (334)

Level of adherence to prescribed exercise in spondyloarthritis and factors affecting this adherence: a systematic review [PDF]

, 2019
Adherence is a primary determinant of the effectiveness of any intervention. Exercise is considered essential in the management of spondyloarthritis (SpA); however, the overall adherence to exercise programmes and factors affecting adherence are unknown.
Coulter, EH, McDonald, DA, McDonald, MT, Paul, L, Siebert, S   +4 more
core   +2 more sources

Racial and Ethnic Disparities Among Participants in US-Based Phase 3 Randomized Cancer Clinical Trials

JNCI Cancer Spectrum, 2020
Although improving representation of racial and ethnic groups in United States clinical trials has been a focus of federal initiatives for nearly 3 decades, the status of racial and ethnic minority enrollment on cancer trials is largely unknown.
Stephen R Grant, Timothy A Lin, Austin B Miller, W. Mainwaring, A. Espinoza, A. Jethanandani, G. Walker, Benjamin D. Smith, B. Guadagnolo, Reshma Jagsi M. D. D. Phil, C., David Fuller, Charles R. Thomas, E. Ludmir   +13 more
semanticscholar   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial

JAMA cardiology, 2019
Importance It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia ...
J. Hochman, H. Reynolds, S. Bangalore, Sean M. O'Brien, K. Alexander, R. Senior, W. Boden, G. Stone, S. Goodman, R. Lopes, J. López-Sendón, H. White, A. Maggioni, L. Shaw, J. Min, M. Picard, D. Berman, B. Chaitman, D. Mark, J. Spertus, D. Cyr, B. Bhargava, W. Rużyłło, G. Wander, A. Chernyavskiy, Y. Rosenberg, D. Maron   +26 more
semanticscholar   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Racial Differences in the Effect of Granulocyte Macrophage Colony-Stimulating Factor on Improved Walking Distance in Peripheral Artery Disease: The PROPEL Randomized Clinical Trial. [PDF]

, 2019
Background The effects of race on response to medical therapy in people with peripheral artery disease ( PAD ) are unknown. Methods and Results In the PROPEL (Progenitor Cell Release Plus Exercise to Improve Functional Performance in PAD) Trial, PAD ...
Criqui, Michael H, Domanchuk, Kathryn, Ferrucci, Luigi, Guralnik, Jack M, Kibbe, Melina R, Li, Lingyu, McDermott, Mary M, Polonsky, Tamar S, Stein, James, Taylor, Doris A, Tian, Lu, Zhao, Lihui   +11 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Mitigating the affective and cognitive consequences of social exclusion: an integrative data analysis of seven social disconnection interventions

BMC Public Health
Background Being socially excluded has detrimental effects, with prolonged exclusion linked to loneliness and social isolation. Social disconnection interventions that do not require direct support actions (e.g., “how can I help?”) offer promise in ...
Randy T. Lee, Gizem Surenkok, Vivian Zayas   +2 more
doaj   +1 more source

Can the palatability of healthy, satiety-promoting foods increase with repeated exposure during weight loss? [PDF]

, 2017
Repeated exposure to sugary, fatty, and salty foods often enhances their appeal. However, it is unknown if exposure influences learned palatability of foods typically promoted as part of a healthy diet.
Anguah, Katherene O.-B., Craig, Bruce A., Eichelsdoerfer, Petra E., Gehrke, Malinda M., Lovejoy, Jennifer C., McCrory, Megan A., Palmer, Philip A.   +6 more
core   +3 more sources