Results 141 to 150 of about 738,443 (251)

The Intellectual Disability Frailty Index Predicts 10-Year Mortality Within the HA-ID Cohort. [PDF]

J Intellect Disabil Res
van Maurik MC, Böhmer MN, Bindels PJE, Festen DAM, Oppewal A.   +4 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

The prevalence and risk factors of drug allergy in Sri Lanka-a multi-centre cross-sectional observational study (2024-2025). [PDF]

Lancet Reg Health Southeast Asia
Liyanage G, Badanasinghe N, Dasanayake D, Prathapan S, West RM, Kudagammana W, Francis V, Suaraweera N, Avello P, Jayawardana P, Krishna MT.   +10 more
europepmc   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Maternal and Newborn Group B <i>Streptococcus</i> Serology in the United States and South Africa. [PDF]

Open Forum Infect Dis
Pahud BA, Madhi SA, Klein NP, Cai B, Scully IL, Gaylord M, Feng Y, Jiang HQ, Swanson KA, Anderson AS, Gurtman A, Munjal I.   +11 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Characterization of von Hippel Lindau gene variants in an African American cohort. [PDF]

HGG Adv
Shao YF, Duque D, Alloghbi AR, Al Share B, Kim S, Kokenakes C, Heath E.   +6 more
europepmc   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

FEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

The link between dental care use and incident diabetes, cancer, and Alzheimer disease among older Americans: the health and retirement study. [PDF]

Saudi Dent J
Agheshteh Sabzevar N, Musaie F, Ostovar Ravari A, Gharehdaghi N, Kianfar K, Ahmadi S, Irannejadrankouhi S, Fazel T, Sadeghi S, Yarahmadi D, Yarahmadi D, Malekpour H, Deravi N.   +12 more
europepmc   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source