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Unnatural Amino Acid Mutagenesis of Fluorescent Proteins†
Angewandte Chemie - International Edition, 2012Jiantao Guo, Feng Wang, Peter G. Schultz
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An unnatural amino acid that mimics phosphotyrosine
Chemical Communications, 2010By replacing the phosphate group in pTyr with an isoxazole carboxylic acid, a novel unnatural amino acid has been successfully synthesized. Subsequently, its incorporation into a known PPI (protein-protein interaction) inhibitor of STAT3 protein (ISS 610) generated I2 which showed reasonable anti-STAT3 activity in both fluorescence polarization and ...
Ge, J., Wu, H., Yao, S.Q.
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Antibody Conjugates with Unnatural Amino Acids
Molecular Pharmaceutics, 2015Antibody conjugates are important in many areas of medicine and biological research, and antibody-drug conjugates (ADCs) are becoming an important next generation class of therapeutics for cancer treatment. Early conjugation technologies relied upon random conjugation to multiple amino acid side chains, resulting in heterogeneous mixtures of labeled ...
Trevor J, Hallam +3 more
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Preparative deracemization of unnatural amino acids
Biochemical Society Transactions, 2006Unnatural amino acids are a growing class of intermediates required for pharmaceuticals, agrochemicals and other industrial products. However, no single method has proven sufficiently versatile to prepare these compounds broadly at scale. To address this need, we have developed a general chemoenzymatic process to prepare enantiomerically pure L- and D ...
Fotheringham, I +4 more
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Regulation of transcription by unnatural amino acids
Nature Biotechnology, 2011Small-molecule regulation of gene expression is intrinsic to cellular function and indispensable to the construction of new biological sensing, control and expression systems. However, there are currently only a handful of strategies for engineering such regulatory components and fewer still that can give rise to an arbitrarily large set of inducible ...
Chang C, Liu +3 more
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Synthesis of Unnatural Amino Acids
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
David J. Ager, Scott A. Laneman
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The unnatural culture of amino acids
Nature Methods, 2007Researchers describe a general and highly efficient approach for incorporating a variety of unnatural amino acids into proteins at desired locations in mammalian cells.
Corinne D Hausmann +2 more
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Applications of Unnatural Amino Acids in Protease Probes
Chemistry – An Asian Journal, 2019AbstractSince proteases are involved in a wide range of physiological and disease states, the development of novel tools for imaging proteolytic enzyme activity is attracting increasing interest from scientists. Peptide substrates containing proteinogenic amino acids are often the first line of defining enzyme specificity.
Izabela Maluch +2 more
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Genetic incorporation of recycled unnatural amino acids
Amino Acids, 2015The genetic incorporation of unnatural amino acids (UAAs) into proteins has been a useful tool for protein engineering. However, most UAAs are expensive, and the method requires a high concentration of UAAs, which has been a drawback of the technology, especially for large-scale applications.
Wooseok, Ko +3 more
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Unnatural amino acids: production and biotechnological potential
World Journal of Microbiology and Biotechnology, 2019Unnatural amino acids (UAAs) are valuable building blocks in the manufacture of a wide range of pharmaceuticals. UAAs exhibit biological activity as free acids and they can be incorporated into linear or cyclic peptides with biological activity.
Tanja Narancic +2 more
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