Results 271 to 280 of about 1,161,651 (341)

Synthesis of Unnatural Amino Acids

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
David J. Ager, Scott A. Laneman
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Genetic incorporation of recycled unnatural amino acids

Amino Acids, 2015
The genetic incorporation of unnatural amino acids (UAAs) into proteins has been a useful tool for protein engineering. However, most UAAs are expensive, and the method requires a high concentration of UAAs, which has been a drawback of the technology, especially for large-scale applications.
Wooseok, Ko, Sanggil, Kim, Kyubong, Jo, Hyun Soo, Lee   +3 more
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Site-specific mutagenesis with unnatural amino acids

Trends in Biochemical Sciences, 1989
The incorporation of unnatural amino acids into proteins by site-specific mutagenesis provides a valuable new methodology for the generation of novel proteins that possess unique structural and functional features.
S J, Anthony-Cahill, M C, Griffith, C J, Noren, D J, Suich, P G, Schultz   +4 more
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Photoinduced C(sp3)-H Functionalization of Glycine Derivatives: Preparation of Unnatural α-Amino Acids and Late-Stage Modification of Peptides.

Accounts of Chemical Research, 2023
ConspectusPeptides are essential components of living systems and contribute to critical biological processes, such as cell proliferation, immune defense, tumor formation, and differentiation.
Chao Wang, Rupeng Qi, Rui Wang, Zhao-Qin Xu   +3 more
semanticscholar   +1 more source

Microwave-assisted synthesis of unnatural amino acids

Bioorganic & Medicinal Chemistry Letters, 2008
Microwave irradiation has been proven to be a useful tool in the rapid assembly of racemic unnatural amino acids in only two steps. Additional benefits of this methodology are the commercial availability of the inexpensive starting materials and the high yields and high purities of the final amino acid products.
Douglas D, Young, Jessica, Torres-Kolbus, Alexander, Deiters   +2 more
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An unnatural amino acid that mimics phosphotyrosine

Chemical Communications, 2010
By replacing the phosphate group in pTyr with an isoxazole carboxylic acid, a novel unnatural amino acid has been successfully synthesized. Subsequently, its incorporation into a known PPI (protein-protein interaction) inhibitor of STAT3 protein (ISS 610) generated I2 which showed reasonable anti-STAT3 activity in both fluorescence polarization and ...
Ge, J., Wu, H., Yao, S.Q.
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Probing Protein Stability with Unnatural Amino Acids

Science, 1992
Unnatural amino acid mutagenesis, in combination with molecular modeling and simulation techniques, was used to probe the effect of side chain structure on protein stability. Specific replacements at position 133 in T4 lysozyme included (i) leucine (wt), norvaline, ethylglycine, and alanine to measure the cost of stepwise removal of methyl
D, Mendel, J A, Ellman, Z, Chang, D L, Veenstra, P A, Kollman, P G, Schultz   +5 more
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Unnatural amino acids: production and biotechnological potential

World Journal of Microbiology and Biotechnology, 2019
Unnatural amino acids (UAAs) are valuable building blocks in the manufacture of a wide range of pharmaceuticals. UAAs exhibit biological activity as free acids and they can be incorporated into linear or cyclic peptides with biological activity.
Tanja Narancic, Sarah A. Almahboub, Kevin E. O’Connor   +2 more
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Unnatural Amino Acids in Novel Antibody Conjugates

Future Medicinal Chemistry, 2014
Antibody-drug conjugates are an important and emerging drug class for the treatment of cancer. Recent evidence strongly suggests that site-specific drug conjugation results in a homogenous population of molecules with more favorable activity and pharmacokinetic properties than randomly conjugated antibodies.
Trevor J, Hallam, Vaughn V, Smider
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ChemInform Abstract: Unnatural Amino Acids

ChemInform, 2008
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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