Results 171 to 180 of about 33,743 (304)

Ufmylation‐Deficient DDRGK1 Ameliorates Obesity by Inhibiting FASN‐Mediated Adipocyte Lipogenesis

Advanced Science, EarlyView.
DDRGK1 regulates de novo lipogenesis via stabilization of fatty acid synthase (FASN). DDRGK1‐mediated UFMylation of FASN prevents its ubiquitin–proteasomal degradation. Reduced DDRGK1 expression or mutation at the key UFMylation site enhances FASN degradation and suppresses fatty acid synthesis (FAS), resulting in smaller adipocytes and improved ...
Yin Li, Tangjun Zhou, Xiao Yang, Kewei Rong, Xiankun Cao, Lei Shi, Xin Wang, Hongjin Wan, Lei Cui, Kexin Liu, Tong Xing, Hang Zhang, Chen Zhao, Tingxian Guo, Peixiang Ma, Jie Zhao, An Qin   +16 more
wiley   +1 more source

Expedient Synthesis of <i>N</i>-Protected/<i>C</i>-Activated Unnatural Amino Acids for Direct Peptide Synthesis. [PDF]

J Am Chem Soc
Kohnke P, Zhang L.
europepmc   +1 more source

Irgm1 Improves Postinfarction Cardiac Repair by Promoting Neutrophil Clearance and Efferocytosis

Advanced Science, EarlyView.
The Irgm1‐PDIA3 axis enhances post‐infarction cardiac repair by accelerating neutrophil clearance and facilitating efferocytosis. Irgm1 holds potential as a prognostic biomarker in MI, and LOC14 may represent a therapeutic option to improve cardiac repair, especially in cases of Irgm1 deficiency.
Zeng Wang, Lai Wei, Mingyang Wang, Shanjie Wang, Lili Xiu, Jiaxiang Sun, Rongzhe Lu, Yige Liu, Jiaxin Wang, Fengyi Liu, Weike Liu, Bo Yu, Yong Sun, Xueqin Gao, Shaohong Fang   +14 more
wiley   +1 more source

Expanding the Repertoire of Photoswitchable Unnatural Amino Acids for Enzyme Engineering. [PDF]

Angew Chem Int Ed Engl
Hiefinger C, Marcon M, Pape V, Casadevall G, Lahmy R, Haag C, Nazet J, Bartl M, Bruckmann A, Osuna S, König B, Hupfeld A.   +11 more
europepmc   +1 more source

Synthesis, Antitumor and Antibacterial Studies of New Shortened Analogues of (KLAKLAK)₂-NH₂ and Their Conjugates Containing Unnatural Amino Acids. [PDF]

Molecules, 2021
Jaber S, Iliev I, Angelova T, Nemska V, Sulikovska I, Naydenova E, Georgieva N, Givechev I, Grabchev I, Danalev D.   +9 more
europepmc   +1 more source

Resolvin D5 Inhibits CXCL8 Expression in Colonic Epithelial Cells Through Activating GPR101 to Impede Neutrophil Recruitment and Consequently Alleviate Ulcerative Colitis

Advanced Science, EarlyView.
RvD5 effectively alleviates UC by inhibiting STAT1 signaling to reduce CXCL8 expression in colonic epithelial cells via activation of GPR101, which subsequently decreases the infiltration of neutrophils in the colonic mucosal epithelium. Epimedin A1, a natural allosteric inhibitor of 5‐LOX, demonstrates potential as a therapeutic agent for UC by ...
Pengxiang Guo, Yilei Guo, Yanrong Zhu, Ke Yan, Yulai Fang, Jiafeng Zhang, Yue He, Zhifeng Wei, Yufeng Xia, Yue Dai   +9 more
wiley   +1 more source

Expanding the fluorescence toolkit: molecular design, synthesis and biological application of unnatural amino acids. [PDF]

Chem Sci
Marshall O, Sutherland A.
europepmc   +1 more source

Using unnatural amino acids to selectively label proteins for cellular imaging: a cell biologist viewpoint. [PDF]

FEBS J, 2021
Elia N.
europepmc   +1 more source

Phase Separation of NFIB Suppresses SLC3A2‐Mediated Ferroptosis in Castration‐Resistant Prostate Cancer

Advanced Science, EarlyView.
Castration‐resistant prostate cancer (CRPC) remains sensitive to ferroptosis, but its intrinsic resistance is poorly understood. Here, we identify NFIB as a master suppressor. SIRT7‐mediated NFIB acetylation drives its liquid–liquid phase separation, which promotes SLC3A2 transcription to inhibit ferroptosis.
Qiunuo Li, Danyang Chen, Yongzhen Xia, Yili Long, Nan Huang, Rongna Li, Mengting Shi, Mairehaba Kadier, Huafeng Luo, Xiaohui Chen, Hao Liu, Guanmin Jiang   +11 more
wiley   +1 more source

Predicting the structures of cyclic peptides containing unnatural amino acids by HighFold2. [PDF]

Brief Bioinform
Zhu C, Cao S, Shang T, Guo J, Su A, Li C, Duan H.   +6 more
europepmc   +1 more source